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Blood, 15 August 2007, Vol. 110, No. 4, pp. 1161-1167.
Prepublished online as a Blood First Edition Paper on April 24, 2007; DOI 10.1182/blood-2007-01-071605.
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Submitted January 31, 2007
Accepted April 22, 2007
Multiple prethymic defects underlie age-related loss of T progenitor competence
Valerie P Zediak, Ivan Maillard, and Avinash Bhandoola*
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, United States
Division of Hematology-Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA, United States
* Corresponding author; email: bhandooa{at}mail.med.upenn.edu.
Aging in mice and humans is characterized by declining T lymphocyte production in the thymus, yet it is unclear whether aging impacts the T lineage potential of hematopoietic progenitors. Although alterations in the lymphoid progenitor content of aged mouse bone marrow (BM) have been described, irradiation-reconstitution experiments have failed to reveal defects in T lineage potential of BM hematopoietic progenitors or purified hematopoietic stem cells (HSC) from aged mice. Here, we assessed T progenitor potential in unmanipulated recipient mice without conditioning irradiation. T progenitor potential was reduced in aged BM compared to young BM, and this reduction was apparent at the earliest stages of intrathymic differentiation. Further, enriched populations of aged HSC or multipotent progenitors (MPP) gave rise to fewer T lineage cells than their young counterparts. Whereas the T precursor frequency within the MPP pool was unchanged, there was a fourfold decline in T precursor frequency within the HSC pool. In addition, among the T-competent HSC clones, there were fewer highly proliferative clones in the aged HSC pool than in the young HSC pool. These results identify T-compromised aged HSC, and define the nature and cellular sites of prethymic, age-related defects in T lineage differentiation potential.
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