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 Blood, 1 October 2007, Vol. 110, No. 7, pp. 2231-2234.
Prepublished online as a Blood First Edition Paper on June 8, 2007; DOI 10.1182/blood-2007-02-071423.

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Submitted February 1, 2007
Accepted June 1, 2007

Donor-derived DNA in fingernails among recipients of allogeneic hematopoietic stem cell transplantation

Daisuke Imanishi, Yasushi Miyazaki*, Reishi Yamasaki, Yasushi Sawayama, Jun Taguchi, Hideki Tsushima, Takuya Fukushima, Shinichiro Yoshida, Hiroshi Sasaki, Tomoko Hata, and Masao Tomonaga

Molecular Medicine Unit and Hematology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
Center for Molecular Biology and Cytogenetics, SRL Inc., Hino, Japan

* Corresponding author; email: y-miyaza{at}nagasaki-u.ac.jp.

To examine whether donor-derived cells could exist in non-hematopoietic tissues of recipients after allogeneic hematopoietic stem cell transplantation, we examined the patterns of short tandem repeat (STR) of DNA extracted from fingernail clippings of recipients so that the contamination of blood cells was excluded. All 21 patients reached donor-derived hematopoiesis after transplantation and 20 of them were in remission of the primary diseases at the time of sampling. Compared with STR of donor cells, among 9 out of 21 patients, DNA extracted from fingernails samples showed co-existence of donor pattern of STR sharing from 8.9% to 72.9% of total STR areas. Time from transplantation to sampling was from 305 to 2399 days among positive cases. These results demonstrate for the first time the existence of stable contribution of donor cells in fingernails among recipients of allogeneic hematopoietic stem cell transplantation.


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Blood 2007 110: 2221. [Full Text] [PDF]



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