SEARCH:   Advanced

Blood, 1 October 2007, Vol. 110, No. 7, pp. 2484-2493. Prepublished online as a Blood First Edition Paper on July 12, 2007; DOI 10.1182/blood-2007-02-076364. This Article Full Text (PDF) Supplemental Figure All Versions of this Article: blood-2007-02-076364v1 110/7/2484    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Zhang, A. L Articles by Soderstrom, K. Search for Related Content PubMed PubMed Citation Articles by Zhang, A. L Articles by Soderstrom, K. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted February 28, 2007 Accepted July 9, 2007 Natural killer cells trigger differentiation of monocytes into dendritic cells Angela L Zhang, Paula Colmenero, Ulrich Purath, Cristina Teixeira de Matos, Wolfgang Hueber, Lars Klareskog, Ingo H Tarner, Edgar G Engleman, and Kalle Soderstrom* Department of Pathology, Stanford University School of Medicine, Palo Alto, CA, United States Div. of Rheumatology and Clinical Immunology, Kerckhoff-Klinik, Bad Nauheim, Germany Microbiology and Tumor Biology Center (MTC), Karolinska Institute, Stockholm, Sweden Geriatric Research, Education and Clinical Center (GRECC), Stanford University School of Medicine, Palo Alto, CA, United States Rheumatology Unit, Department of Medicine at Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden * Corresponding author; email: kalsod{at}stanford.edu. Circulating monocytes can differentiate into dendritic cells (moDC), which are potent inducers of adaptive immune responses. Previous reports show that GM-CSF and IL-4 induce monocyte differentiation into moDC in vitro, but little is known about the physiological requirements that initiate moDC differentiation in vivo. Here we show that a unique NK cell subset (CD3-CD56bright) that accumulates in lymph nodes and chronically inflamed tissues triggers CD14+ monocytes to differentiate into potent T-helper-1 (TH1) promoting DC. This process requires direct contact of monocytes with NK cells and is mediated by GM-CSF and CD154 derived from NK cells. Importantly, synovial fluid (SF) from patients with rheumatoid arthritis (RA) and psoriatic arthritis (PsA), but not osteoarthritis (OA), induces monocytes to differentiate into DC. However, this process occurs only in the presence of NK cells. We propose that NK cells play a role in the maintenance of TH1 mediated inflammatory diseases such as RA, by providing a local milieu for monocytes to differentiate into DC. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M. Hiasa, M. Abe, A. Nakano, A. Oda, H. Amou, S. Kido, K. Takeuchi, K. Kagawa, K. Yata, T. Hashimoto, et al. GM-CSF and IL-4 induce dendritic cell differentiation and disrupt osteoclastogenesis through M-CSF receptor shedding by up-regulation of TNF-{alpha} converting enzyme (TACE) Blood, November 12, 2009; 114(20): 4517 - 4526. [Abstract] [Full Text] [PDF] C Plater-Zyberk, L A B Joosten, M M A Helsen, M I Koenders, P A Baeuerle, and W B van den Berg Combined blockade of granulocyte-macrophage colony stimulating factor and interleukin 17 pathways potently suppresses chronic destructive arthritis in a tumour necrosis factor {alpha}-independent mouse model Ann Rheum Dis, May 1, 2009; 68(5): 721 - 728. [Abstract] [Full Text] [PDF] P. Krause, M. Bruckner, C. Uermosi, E. Singer, M. Groettrup, and D. F. Legler Prostaglandin E2 enhances T-cell proliferation by inducing the costimulatory molecules OX40L, CD70, and 4-1BBL on dendritic cells Blood, March 12, 2009; 113(11): 2451 - 2460. [Abstract] [Full Text] [PDF] S. Saghafian-Hedengren, Y. Sundstrom, E. Sohlberg, C. Nilsson, A. Linde, M. Troye-Blomberg, L. Berg, and E. Sverremark-Ekstrom Herpesvirus Seropositivity in Childhood Associates with Decreased Monocyte-Induced NK Cell IFN-{gamma} Production J. Immunol., February 15, 2009; 182(4): 2511 - 2517. [Abstract] [Full Text] [PDF] S. Mariotti, V. Sargentini, C. Marcantonio, E. Todero, R. Teloni, M. C. Gagliardi, A. R. Ciccaglione, and R. Nisini T-cell-mediated and antigen-dependent differentiation of human monocyte into different dendritic cell subsets: a feedback control of Th1/Th2 responses FASEB J, September 1, 2008; 22(9): 3370 - 3379. [Abstract] [Full Text] [PDF] M. Moreno, J. W. Molling, S. von Mensdorff-Pouilly, R. H. M. Verheijen, E. Hooijberg, D. Kramer, A. W. Reurs, A. J. M. van den Eertwegh, B. M. E. von Blomberg, R. J. Scheper, et al. IFN-{gamma}-Producing Human Invariant NKT Cells Promote Tumor-Associated Antigen-Specific Cytotoxic T Cell Responses J. Immunol., August 15, 2008; 181(4): 2446 - 2454. [Abstract] [Full Text] [PDF] A. Iannello, O. Debbeche, S. Samarani, and A. Ahmad Antiviral NK cell responses in HIV infection: I. NK cell receptor genes as determinants of HIV resistance and progression to AIDS J. Leukoc. Biol., July 1, 2008; 84(1): 1 - 26. [Abstract] [Full Text] [PDF]

	Copyright © 2007 by American Society of Hematology         Online ISSN: 1528-0020