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Blood, 15 September 2007, Vol. 110, No. 6, pp. 1713-1722.
Prepublished online as a Blood First Edition Paper on May 31, 2007; DOI 10.1182/blood-2007-03-055749.
Previous Article | Next Article 
Submitted March 6, 2007
Accepted April 18, 2007
Revisions to the staging and classification of mycosis
fungoides and Sezary syndrome: a proposal of the
International Society for Cutaneous Lymphomas (ISCL) and
the Cutaneous Lymphoma Task Force of the European
Organization of Research and Treatment of Cancer (EORTC)
Elise Olsen*, Eric Vonderheid, Nicola Pimpinelli, Rein Willemze, Youn Kim, Robert Knobler, Herschel Zackheim, Madeleine Duvic, Teresa Estrach, Stanford I Lamberg, Gary Wood, Reinhard Dummer, Annamari Ranki, Gunter Burg, Peter Heald, Mark Pittelkow, Maria-Grazia Bernengo, Wolfram Sterry, Liliane Laroche, Franz Trautinger, and Sean Whittaker
Department of Medicine, Divisions of Dermatology & Oncology, Duke University Medical Center, Durham, NC, United States
Department of Dermatology, Johns Hopkins University, Baltimore, MD, United States
Department of Dermatological Sciences, University of Florence, Florence, Italy
Department of Dermatology, Leiden University Medical Center, Leiden, Netherlands
Department of Dermatology, Stanford University Medical Center, Stanford, CA, United States
Department of Dermatology, University of Vienna, Vienna, Austria
Department of Dermatology, University of California at San Francisco, San Francisco, CA, United States
Department of Dermatology, University of Texas at Houston, Houston, TX, United States
Department of Dermatology, University of Barcelona, Barcelona, Spain
Department of Dermatology, University of Wisconsin, Madison, WI, United States
Deparment of Dermatology, University Hospital Zurich, Zurich, Switzerland
Department of Dermatology and Venereal Diseases, Helsinki University Hospital, Helsinki, Finland
Department of Dermatology, University Hospital Zurich, Zurich, Switzerland
Department of Dermatology, Yale University, New Haven, CT, United States
Department of Dermatology, Mayo Clinic, Rochester, MN, United States
Department of Dermatology, University of Turin, Turin, Italy
Department of Dermatology, Charite, Humboldt University, Berlin, Germany
Department of Immuno-Dermatology, Hospital Avicenne - University of Paris XIII, Paris, France
Skin Tumour Unit, St . John's Institute of Dermatology, St. Thomas' Hospital, London, United Kingdom
* Corresponding author; email: olsen001{at}mc.duke.edu.
The ISCL/EORTC recommends revisions to the Mycosis Fungoides Cooperative Group classification and staging system for Cutaneous T-cell Lymphoma. (CTCL). These revisions are made to incorporate advances related to tumor cell biology and diagnostic techniques as pertains to mycosis fungoides (MF) and Sezary Syndrome (SS) since the 1979 publication of the original guidelines, to clarify certain variables that currently impede effective inter-institution and inter-investigator communication and/or the development of standardized clinical trials in MF and SS, and to provide a platform for tracking other variables of potential prognostic significance. Moreover, given the difference in prognosis and clinical characteristics of the non-MF/non-SS subtypes of cutaneous lymphoma, this revision pertains specifically to MF and SS. The evidence supporting the revisions is discussed as well as recommendations for evaluation and staging procedures based on these revisions.

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