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Blood, 1 October 2007, Vol. 110, No. 7, pp. 2250-2258. Prepublished online as a Blood First Edition Paper on May 14, 2007; DOI 10.1182/blood-2007-03-077602. This Article Full Text (PDF) All Versions of this Article: blood-2007-03-077602v1 110/7/2250    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Cserti, C. M Articles by Dzik, W. H Search for Related Content PubMed PubMed Citation Articles by Cserti, C. M Articles by Dzik, W. H Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted March 1, 2007 Accepted May 10, 2007 The ABO blood group system and plasmodium falciparum malaria Christine M Cserti* and Walter H Dzik Blood Transfusion Laboratory, University Health Network, Toronto General Hospital, Toronto, Ontario, Canada Blood Transfusion Service, Massachusetts General Hospital, Boston, MA, United States * Corresponding author; email: christine.cserti{at}uhn.on.ca. In the century since the discovery of the ABO blood groups, numerous associations between ABO groups and disease have been noted. However, the selection pressures defining the ABO distributions remain uncertain. We review published information on Plasmodium falciparum infection and ABO blood groups. DNA sequence information dates the emergence and development of the group O allele to a period of evolution prior to human migration out of Africa, concomitant with P. falciparum's activity. The current geographic distribution of group O is also consistent with a selection pressure by P. falciparum in favor of group O individuals in malaria endemic regions. We critically review clinical reports of ABO and P. falciparum infection, documenting a correlation between disease severity and ABO group. Finally, we review published data on the pathogenesis of P. falciparum infection, and propose a biologic model to summarize the role of ABO blood groups in cytoadherence biology. Such ABO-related mechanisms also point to a new hypothesis to account for selection of the Le(a-b-) phenotype. Taken together, a broad range of available evidence suggests that the origin, distribution, and relative proportion of ABO blood groups in humans may have been directly influenced by selective genetic pressure from P. falciparum infection. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: P. M. Durand and T. L. Coetzer Hereditary red cell disorders and malaria resistance Haematologica, July 1, 2008; 93(7): 961 - 963. [Full Text] [PDF] A. E. Fry, M. J. Griffiths, S. Auburn, M. Diakite, J. T. Forton, A. Green, A. Richardson, J. Wilson, M. Jallow, F. Sisay-Joof, et al. Common variation in the ABO glycosyltransferase is associated with susceptibility to severe Plasmodium falciparum malaria Hum. Mol. Genet., February 14, 2008; 17(4): 567 - 576. [Abstract] [Full Text] [PDF] J. A. Rowe, I. G. Handel, M. A. Thera, A.-M. Deans, K. E. Lyke, A. Kone, D. A. Diallo, A. Raza, O. Kai, K. Marsh, et al. Blood group O protects against severe Plasmodium falciparum malaria through the mechanism of reduced rosetting PNAS, October 30, 2007; 104(44): 17471 - 17476. [Abstract] [Full Text] [PDF]

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