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Blood, 1 October 2007, Vol. 110, No. 7, pp. 2757-2760. Prepublished online as a Blood First Edition Paper on June 19, 2007; DOI 10.1182/blood-2007-03-080820. This Article Full Text (PDF) All Versions of this Article: blood-2007-03-080820v1 110/7/2757    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Lilleri, D. Articles by Locatelli, F. Search for Related Content PubMed PubMed Citation Articles by Lilleri, D. Articles by Locatelli, F. Related Collections Related Articles in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted March 19, 2007 Accepted June 11, 2007 Use of a DNAemia cut-off for monitoring human cytomegalovirus infection reduces the number of pre-emptively treated children and young adults receiving haematopoietic stem cell transplantation as compared to qualitative pp65-antigenemia Daniele Lilleri, Giuseppe Gerna*, Milena Furione, Maria Ester Bernardo, Giovanna Giorgiani, Stefania Telli, Fausto Baldanti, and Franco Locatelli Servizio di Virologia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy Oncoematologia Pediatrica, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy * Corresponding author; email: g.gerna{at}smatteo.pv.it. We performed a randomised trial comparing the use of quantitative DNAemia versus positive antigenemia for starting pre-emptive anti-human cytomegalovirus (HCMV) therapy in hematopoietic stem cell transplantation (HSCT) recipients. In the DNAemia arm, antiviral therapy was initiated upon reaching a DNAemia cut-off of 10,000 DNA copies/ml whole blood, whereas in the antigenemia arm therapy was started in the presence of a positive antigenemia. Aim of the study was to compare the number of patients treated in the two arms. On the whole, 178 patients (89 in each arm), receiving unmanipulated HSCT from either a relative or an unrelated donor, completed the study. While the incidence of HCMV infection was comparable in DNAemia and antigenemia arms (34% vs 42%, respectively, P=0.259), number of patients treated was significantly lower in the DNAemia arm (18% vs 31%, respectively, P=0.026). No patient developed HCMV disease. The use of a DNAemia cut-off avoids unnecessary anti-viral treatment. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Articles in Blood Online: Clarification of data used in three studies on MCA-induction of sarcoma in mice Mark J. Smyth Blood 2008 111: 4419. [Full Text] [PDF] Response: Human cytomegalovirus DNAemia and preemptive treatment of HCMV infection in children receiving hematopoietic stem-cell transplantation Giuseppe Gerna, Daniele Lilleri, and Franco Locatelli Blood 2008 111: 4420. [Full Text] [PDF] This article has been cited by other articles: G. Gerna, D. Lilleri, and F. Locatelli Response: Human cytomegalovirus DNAemia and preemptive treatment of HCMV infection in children receiving hematopoietic stem-cell transplantation Blood, April 15, 2008; 111(8): 4420 - 4420. [Full Text] [PDF] S. Cesaro, D. Abate, and C. Mengoli Human cytomegalovirus DNAemia and preemptive treatment of CMV infection in children after hematopoietic stem-cell transplantation: Is any question settled? Blood, April 15, 2008; 111(8): 4419 - 4419. [Full Text] [PDF]

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