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Blood, 1 November 2007, Vol. 110, No. 9, pp. 3310-3315. Prepublished online as a Blood First Edition Paper on July 13, 2007; DOI 10.1182/blood-2007-05-086934. This Article Full Text (PDF) All Versions of this Article: blood-2007-05-086934v1 110/9/3310    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Niens, M. Articles by van den Berg, A. Search for Related Content PubMed PubMed Citation Articles by Niens, M. Articles by van den Berg, A. Related Collections Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted May 18, 2007 Accepted July 11, 2007 HLA-A*02 is associated with a reduced risk and HLA-A*01 with an increased risk of developing EBV-positive Hodgkin lymphoma Marijke Niens, Ruth F Jarrett, Bouke Hepkema, Ilja M Nolte, Arjan Diepstra, Mathieu Platteel, Niels Kouprie, Craig P Delury, Alice Gallagher, Lydia Visser, Sibrand Poppema, Gerard J te Meerman, and Anke van den Berg* Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, Netherlands LRF Virus Centre, Institute of Comparative Medicine, University of Glasgow, Glasgow, United Kingdom Department of Transplantation Immunology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands Department of Pathology and Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, Netherlands * Corresponding author; email: a.van.den.berg{at}path.umcg.nl. Previous studies showed that the HLA class I region is associated with Epstein-Barr virus (EBV) positive Hodgkin lymphoma (HL) and that HLA-A is the most likely candidate gene in this region. This suggests that antigenic presentation of EBV-derived peptides in the context of HLA-A is involved in the pathogenesis of EBV-positive HL by precluding efficient immune responses. We genotyped exons 2 and 3, encoding the peptide-binding groove of HLA-A, for 32 single nucleotide polymorphisms in 70 EBV-positive and 31 EBV-negative HL patients and 59 controls. HLA-A*01 was significantly overrepresented and HLA-A*02 was significantly underrepresented in EBV-positive HL patients versus controls and EBV-negative HL patients. In addition, HLA-A*02 status was determined by immunohistochemistry or HLA-A*02 specific PCR on 152 EBV-positive and 322 EBV-negative HL cases. The percentage of HLA-A*02 positive patients in the EBV-positive HL group (35.5%) was significantly lower than in 6107 general controls (53.0%) and the EBV-negative HL group (50.9%). Our results indicate that individuals carrying the HLA-A*02 allele have a reduced risk of developing EBV-positive HL, while individuals carrying the HLA-A*01 allele have an increased risk. It is known that HLA-A*02 can present EBV-derived peptides and can evoke an effective immune response, which may explain the protective phenotype. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: A mechanism for the HLA-A*01–associated risk for EBV+ Hodgkin lymphoma and infectious mononucleosis Rebekah M. Brennan and Scott R. Burrows Blood 2008 112: 2589-2590. [Full Text] [PDF] This article has been cited by other articles: M. L. Gulley and W. Tang Laboratory Assays for Epstein-Barr Virus-Related Disease J. Mol. Diagn., July 1, 2008; 10(4): 279 - 292. [Abstract] [Full Text] [PDF]

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