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Blood, 15 December 2007, Vol. 110, No. 13, pp. 4455-4463. Prepublished online as a Blood First Edition Paper on September 7, 2007; DOI 10.1182/blood-2007-05-088682. This Article Full Text (PDF) Supplemental Tables and Figure All Versions of this Article: blood-2007-05-088682v1 110/13/4455    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Cerhan, J. R. Articles by Slager, S. L. Search for Related Content PubMed PubMed Citation Articles by Cerhan, J. R. Articles by Slager, S. L. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted May 3, 2007 Accepted September 2, 2007 Genetic variation in 1253 immune and inflammation genes and risk of non-Hodgkin lymphoma James R. Cerhan*, Stephen M. Ansell, Zachary S. Fredericksen, Neil E. Kay, Mark Liebow, Timothy G. Call, Ahmet Dogan, Julie M. Cunningham, Alice H. Wang, Wen Liu-Mares, William R. Macon, Diane Jelinek, Thomas E. Witzig, Thomas M. Habermann, and Susan L. Slager Division of Epidemiology, Dept of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN, United States Division of Biostatistics, Dept of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN, United States Division of Hematology, Dept of Medicine, Mayo Clinic College of Medicine, Rochester, MN, United States Division of General Internal Medicine, Dept of Medicine, Mayo Clinic College of Medicine, Rochester, MN, United States Division of Hematopathology, Dept of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN, United States Division of Experimental Pathogy, Dept of Laboratory medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN, United States Department of Immunology, Mayo Clinic College of Medicine, Rochester, MN, United States * Corresponding author; email: cerhan.james{at}mayo.edu. Smaller scale evaluations suggest that common genetic variation in candidate genes related to immune function may predispose to the development of NHL. We report an analysis of variants within genes associated with immunity and inflammation and risk of NHL using a panel of 9,412 single nucleotide polymorphisms (SNPs) from 1,253 genes in a study of 458 NHL cases and 484 frequency matched controls. We modeled haplotypes and risk of NHL, as well as the main effects for all independent SNPs from a gene in multivariate logistic regression models; we separately report results for non-synonymous (ns) SNPs. In gene-level analyses, the strongest findings (p0.001) were for CREB1, FGG, MAP3K5, RIPK3, LSP1, TRAF1, DUSP2, and ITGB3. In nsSNP analyses, the strongest findings (p0.01) were for ITGB3 L59P (OR=0.66, 0.52-0.85), TLR6 V427A (OR=5.20, 1.77-15.3), SELPLG M264V (OR=3.20, 1.48-6.91), UNC84B G671S (OR=1.50, 1.12-2.00), B3GNT3 H328R (OR=0.74, 0.59-0.93), and BAT2 V1883L (OR=0.64, 0.45-0.90). Our results suggest that genetic variation in genes associated with immune response (TRAF1, RIPK3, BAT2, TLR6), MAPK signaling (MAP3K5, DUSP2 and CREB1), lymphocyte trafficking and migration (B3GNT3, SELPLG, LSP1), and coagulation pathways (FGG, ITGB3) may be important in the etiology of NHL, and should be prioritized in replication studies. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

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