|
|
Blood, 15 April 2008, Vol. 111, No. 8, pp. 4096-4105.
Prepublished online as a Blood First Edition Paper on December 21, 2007; DOI 10.1182/blood-2007-05-089565.
 Previous Article | Next Article 
Submitted May 14, 2007
Accepted December 13, 2007
GAS6 promotes inflammation by enhancing interactions between endothelial cells, platelets and leukocytes
Marc Tjwa, Lola Bellido-Martin, Yuan Lin, Esther Lutgens, Stephane Plaisance, Francoise Bono, Nathalie Delesque-Touchard, Caroline Herve, Rute Moura, An D. Billiau, Cristina Aparicio, Marcel Levi, Mat Daemen, Mieke Dewerchin, Florea Lupu, Jef Arnout, Jean-Marc Herbert, Mark Waer, Pablo Garcia de Frutos, Bjorn Dahlback, Peter Carmeliet*, Marc F. Hoylaerts, and Lieve Moons
Department for Transgene Technology and Gene Therapy, VIB, Leuven, Belgium
IIBB-IDIBAPS-CSIC, Instituto de Investigaciones Biomedicas de Barcelona, Barcelona, Spain
Laboratory of Experimental Transplantation, K.U. Leuven, Leuven, Belgium
Department of Pathology, University of Maastricht, Maastricht, Netherlands
Center of Transgene Technology and Gene Tehrapy, K.U. Leuven, Leuven, Belgium
Cardiovascular-Thrombosis Research Department, Sanofi~Aventis, Toulouse, France
Center for Molecular and Vascular Biology, K.U. Leuven, Leuven, Belgium
Department of Clinical Chemistry, University of Lund, Malmo, Sweden
Cardiovascular Research Program, Oklahoma Medical Research Foundation, OK, United States
* Corresponding author; email: peter.carmeliet{at}med.kuleuven.be.
The role of Gas6 in endothelial cell (EC) function remains incompletely characterized. Here, we report that Gas6 amplifies EC activation in response to inflammatory stimuli in vitro. In vivo, Gas6 promotes and accelerates the sequestration of circulating platelets and leukocytes on activated endothelium as well as the formation and endothelial sequestration of circulating platelet-leukocyte conjugates. In addition, Gas6 promotes leukocyte extravasation, inflammation and thrombosis in mouse models of inflammation (endotoxinemia, vasculitis, heart transplantation). Thus, Gas6 amplifies EC activation, thereby playing a key role in enhancing the interactions between ECs, platelets and leukocytes during inflammation.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
Related Article in Blood Online:
-
Gas6 inflames cell interactions
- Delphine Borgel
Blood 2008 111: 3915.
[Full Text]
[PDF]
This article has been cited by other articles:
|
|
|
|
 
J. C McCann and B. N Ames
Vitamin K, an example of triage theory: is micronutrient inadequacy linked to diseases of aging?
Am. J. Clinical Nutrition,
October 1, 2009;
90(4):
889 - 907.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Scutera, T. Fraone, T. Musso, P. Cappello, S. Rossi, D. Pierobon, Z. Orinska, R. Paus, S. Bulfone-Paus, and M. Giovarelli
Survival and Migration of Human Dendritic Cells Are Regulated by an IFN-{alpha}-Inducible Axl/Gas6 Pathway
J. Immunol.,
September 1, 2009;
183(5):
3004 - 3013.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J.-K. Park, S. Theuer, T. Kirsch, C. Lindschau, U. Klinge, A. Heuser, R. Plehm, M. Todiras, P. Carmeliet, H. Haller, et al.
Growth Arrest Specific Protein 6 Participates in DOCA-Induced Target-Organ Damage
Hypertension,
August 1, 2009;
54(2):
359 - 364.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
