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Blood, 15 February 2008, Vol. 111, No. 4, pp. 2246-2252. Prepublished online as a Blood First Edition Paper on November 28, 2007; DOI 10.1182/blood-2007-05-092759. This Article Full Text (PDF) All Versions of this Article: blood-2007-05-092759v1 111/4/2246    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Roos, G. Articles by Stilgenbauer, S. Search for Related Content PubMed PubMed Citation Articles by Roos, G. Articles by Stilgenbauer, S. Related Collections Related Articles in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted May 30, 2007 Accepted November 16, 2007 Short telomeres are associated with genetic complexity, high risk genomic aberrations, and short survival in chronic lymphocytic leukemia Goran Roos*, Alexander Krober, Pawel Grabowski, Dirk Kienle, Andreas Buhler, Hartmut Dohner, Richard Rosenquist, and Stephan Stilgenbauer Department of Medical Biosciences, Umea University, Umea, Sweden Innere Medizin III, Universitat Ulm, Ulm, Germany Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden * Corresponding author; email: goran.roos{at}medbio.umu.se. Telomere length is associated with mutation status of the immunoglobulin heavy chain variable (IGHV) gene and clinical course in B-cell chronic lymphocytic leukemia (B-CLL). In a B-CLL cohort of 152 patients, we analyzed telomere length, genomic aberrations, IGHV mutation status, CD38 and ZAP-70 expression, to study the prognostic impact and associations among these factors. An inverse correlation existed between telomere length and IGHV homology (p<0.001), CD38 (p<0.001) and ZAP-70 expression (p=0.01). Cases with telomere lengths below median (i.e. "short telomeres") and above median (i.e. "long telomeres") had similar incidences of genomic aberrations (74 vs. 68%), 13q- (57 vs. 49%) and +12q (5 vs. 12%). In contrast, 13q- as a single aberration was more frequent in cases with long telomeres (51 vs. 21%, p=0.006), whereas 11q- (27 vs. 9%, p=0.014), 17p- (17 vs. 0%, p<0.001) and two or more genomic aberrations (39 vs. 8%, p<0.001) were more frequent in cases with short telomeres. Compared to cases with long telomeres treatment free survival (TFS) and overall survival (OS) was significantly shorter (p<0.001 and p=0.015, respectively) in the group with short telomeres, and telomere length was an independent prognostic indicator for TFS. These observations have biological and prognostic implications in B-CLL. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Articles in Blood Online: Short telomeres in B-CLL: the chicken or the egg? Bernd Jahrsdörfer and George J. Weiner Blood 2008 111: 5756. [Full Text] [PDF] Response: Or both? Göran Roos, Richard Rosenquist, and Stephan Stilgenbauer Blood 2008 111: 5756-5757. [Full Text] [PDF] Do short telomeres shorten CLL survival? Thomas S. Lin Blood 2008 111: 1755. [Full Text] [PDF] This article has been cited by other articles: B. Jahrsdorfer and G. J. Weiner Short telomeres in B-CLL: the chicken or the egg? Blood, June 15, 2008; 111(12): 5756 - 5756. [Full Text] [PDF] G. Roos, R. Rosenquist, and S. Stilgenbauer Response: Or both? Blood, June 15, 2008; 111(12): 5756 - 5757. [Full Text] [PDF]

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