Blood online
Home About Blood Authors Subscriptions Permission Advertising Public Access contact us
 

 
Advanced
Current Issue
First Edition
Future Articles
Archives
Submit to Blood
Search
American Society of Hematology
Meeting Abstracts
Email Alerts
 Blood, 15 February 2008, Vol. 111, No. 4, pp. 2046-2048.
Prepublished online as a Blood First Edition Paper on November 30, 2007; DOI 10.1182/blood-2007-05-092916.

This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
blood-2007-05-092916v1
111/4/2046    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Right arrow Rights and Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by McDonald, A. G
Right arrow Articles by Hoffman, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by McDonald, A. G
Right arrow Articles by Hoffman, M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

arrow to previous article Previous Article  |  Next Article next article arrow

Submitted May 31, 2007
Accepted November 15, 2007

Perivascular tissue factor is down-regulated following cutaneous wounding: implications for bleeding in hemophilia

Anna G McDonald, Katie Yang, Harold R. Roberts, Dougald M Monroe, and Maureane Hoffman*

Duke University, Durham, NC, United States
Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States
Pathology & Lab Medicine Service, Durham Veterans Affairs Medical Center, Durham, NC, United States

* Corresponding author; email: maureane{at}med.unc.edu.

Healing of skin wounds is delayed in hemophilia B (HB) mice. HB mice do not bleed excessively at wounding, yet re-bleed hours to days later. Tissue factor (TF) expression is upregulated by inflammatory cytokines and has been linked to angiogenesis. We hypothesized that impaired thrombin generation in HB leads to impaired TF expression following injury. Punch biopsies were placed on wild-type (WT) and HB mice. Tissues from wound sites were immunostained for TF. Blood vessels are normally surrounded by a coat of pericytes expressing TF. Surprisingly, within a day after wounding TF disappeared from around nearby vessels; returning after 8 days in WT and 10 days in HB mice. The granulation tissue filling the wound during healing also lacked TF around angiogenic vessels. Thus, perivascular TF expression is down-regulated during wound healing. This may prevent thrombosis of neovessels during angiogenesis, but renders hemophiliacs vulnerable to hemorrhage during healing.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 BloodHome page
J. Sun, N. Hakobyan, L. A. Valentino, B. L. Feldman, R. J. Samulski, and P. E. Monahan
Intraarticular factor IX protein or gene replacement protects against development of hemophilic synovitis in the absence of circulating factor IX
Blood, December 1, 2008; 112(12): 4532 - 4541.
[Abstract] [Full Text] [PDF]


click for free articles
home about blood authors subscriptions permissions advertising public access contact us
  Copyright © 2007 by American Society of Hematology         Online ISSN: 1528-0020