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Blood, 15 December 2007, Vol. 110, No. 13, pp. 4576-4583. Prepublished online as a Blood First Edition Paper on September 4, 2007; DOI 10.1182/blood-2007-06-097386. This Article Full Text (PDF) Supplemental Table All Versions of this Article: blood-2007-06-097386v1 110/13/4576    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Lee, S. J Articles by Anasetti, C. Search for Related Content PubMed PubMed Citation Articles by Lee, S. J Articles by Anasetti, C. Related Collections Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted June 25, 2007 Accepted August 24, 2007 High-resolution donor-recipient HLA matching contributes to the success of unrelated donor marrow transplantation Stephanie J Lee*, John Klein, Michael Haagenson, Lee Ann Baxter-Lowe, Dennis L. Confer, Mary Eapen, Marcelo Fernandez-Vina, Neal Flomenberg, Mary Horowitz, Carolyn K Hurley, Harriet Noreen, Machteld Oudshoorn, Effie Petersdorf, Michelle Setterholm, Stephen Spellman, Daniel Weisdorf, Thomas M. Williams, and Claudio Anasetti Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States Center for International Blood & Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI, United States Center for International Blood & Marrow Transplant Research, Minneapolis, MN, United States Department of Surgery, University of California, San Francisco, CA, United States National Marrow Donor Program, Minneapolis, MN, United States Department of Laboratory Medicine, M.D. Anderson Cancer Center, Houston, TX, United States Kimmel Cancer Center, Thomas Jefferson University Hospital, Philadelphia, PA, United States Department of Oncology, Georgetown University Medical Center, Washington, DC, United States Immunology/Histocompatibility Laboratory, University of Minnesota Medical Center, Fairview, MN, United States Europdonor Foundation, Leiden, Netherlands BMT Program, University of Minnesota, Minneapolis, MN, United States Department of Pathology, University of New Mexico, Albuquerque, NM, United States H. Lee Moffitt Cancer Center, Tampa, FL, United States * Corresponding author; email: sjlee{at}fhcrc.org. The relative importance of various HLA loci and the resolution level at which they are matched has not been fully defined for unrelated donor transplantation. To address this question, National Marrow Donor Program® data from 3857 United States transplantations performed from 1988-2003 were analyzed. Patient-donor pairs were fully typed for HLA-A, B, C, DRB1, DQB1, DQA1, DPB1, and DPA1 alleles. High resolution DNA matching for HLA-A, B, C, and DRB1 [8/8 match] was the minimum level of matching associated with the highest survival. A single mismatch detected by low or high resolution DNA testing at HLA-A, B, C or DRB1 [7/8 match] was associated with higher mortality (relative risk 1.25, 95% CI 1.13-1.38, p<0.0001) and 1-yr survival of 43% compared to 52% for 8/8 matched pairs. Single mismatches at HLA-B or HLA-C appear better tolerated than mismatches at HLA-A or HLA-DRB1. Mismatching at two or more loci compounded the risk. Mismatching at HLA-DP or DQ loci and donor factors other than HLA type were not associated with survival. In multivariate modeling, patient age, race, disease stage and CMV status were as predictive of survival as donor HLA matching. High resolution DNA matching for HLA-A, B, C, and DRB1 alleles is associated with higher rates of survival. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: High-risk HLA allele mismatch combinations responsible for severe acute graft-versus-host disease and implication for its molecular mechanism Takakazu Kawase, Yasuo Morishima, Keitaro Matsuo, Koichi Kashiwase, Hidetoshi Inoko, Hiroh Saji, Shunichi Kato, Takeo Juji, Yoshihisa Kodera, and Takehiko Sasazuki, for The Japan Marrow Donor Program Blood 2007 110: 2235-2241. [Abstract] [Full Text] [PDF] This article has been cited by other articles: G. Socie and B. R. Blazar Acute graft-versus-host disease: from the bench to the bedside Blood, November 12, 2009; 114(20): 4327 - 4336. [Abstract] [Full Text] [PDF] M. R. Verneris, C. G. Brunstein, J. Barker, M. L. MacMillan, T. DeFor, D. H. McKenna, M. J. Burke, B. R. Blazar, J. S. Miller, P. B. McGlave, et al. Relapse risk after umbilical cord blood transplantation: enhanced graft-versus-leukemia effect in recipients of 2 units Blood, November 5, 2009; 114(19): 4293 - 4299. [Abstract] [Full Text] [PDF] K. Sugimoto, M. Murata, S. Terakura, and T. Naoe CTL Clones Isolated from an HLA-Cw-Mismatched Bone Marrow Transplant Recipient with Acute Graft-Versus-Host Disease J. Immunol., November 1, 2009; 183(9): 5991 - 5998. [Abstract] [Full Text] [PDF] R. Crocchiolo, E. Zino, L. Vago, R. Oneto, B. Bruno, S. Pollichieni, N. Sacchi, M. P. Sormani, J. Marcon, T. Lamparelli, et al. Nonpermissive HLA-DPB1 disparity is a significant independent risk factor for mortality after unrelated hematopoietic stem cell transplantation Blood, August 13, 2009; 114(7): 1437 - 1444. [Abstract] [Full Text] [PDF] M. Arora, D. J. Weisdorf, S. R. Spellman, M. D. Haagenson, J. P. Klein, C. K. Hurley, G. B. Selby, J. H. Antin, N. A. Kernan, C. Kollman, et al. HLA-Identical Sibling Compared With 8/8 Matched and Mismatched Unrelated Donor Bone Marrow Transplant for Chronic Phase Chronic Myeloid Leukemia J. Clin. Oncol., April 1, 2009; 27(10): 1644 - 1652. [Abstract] [Full Text] [PDF] S. Cooley, E. Trachtenberg, T. L. Bergemann, K. Saeteurn, J. Klein, C. T. Le, S. G. E. Marsh, L. A. Guethlein, P. Parham, J. S. Miller, et al. Donors with group B KIR haplotypes improve relapse-free survival after unrelated hematopoietic cell transplantation for acute myelogenous leukemia Blood, January 15, 2009; 113(3): 726 - 732. [Abstract] [Full Text] [PDF] H. J. Deeg Allogeneic Hematopoietic Cell Transplantation in Older Patients with Myelodysplastic Syndrome ASCO Educational Book, January 1, 2009; 2009(1): 420 - 424. [Abstract] [Full Text] [PDF] J. Schetelig, M. Bornhauser, C. Schmid, B. Hertenstein, R. Schwerdtfeger, H. Martin, M. Stelljes, U. Hegenbart, K. Schafer-Eckart, M. Fussel, et al. Matched Unrelated or Matched Sibling Donors Result in Comparable Survival After Allogeneic Stem-Cell Transplantation in Elderly Patients With Acute Myeloid Leukemia: A Report From the Cooperative German Transplant Study Group J. Clin. Oncol., November 10, 2008; 26(32): 5183 - 5191. [Abstract] [Full Text] [PDF] J. J. Cornelissen Mother and child reunion Blood, October 1, 2008; 112(7): 2604 - 2605. [Full Text] [PDF] N. J. Bunin, S. M. Davies, R. Aplenc, B. M. Camitta, K. B. DeSantes, R. K. Goyal, N. Kapoor, N. A. Kernan, J. Rosenthal, F. O. Smith, et al. Unrelated Donor Bone Marrow Transplantation for Children With Acute Myeloid Leukemia Beyond First Remission or Refractory to Chemotherapy J. Clin. Oncol., September 10, 2008; 26(26): 4326 - 4332. [Abstract] [Full Text] [PDF] N. Kroger Epigenetic Modulation and Other Options to Improve Outcome of Stem Cell Transplantation in MDS Hematology, January 1, 2008; 2008(1): 60 - 67. [Abstract] [Full Text] [PDF] F. R. Appelbaum Allogeneic Hematopoietic Cell Transplantation for Acute Myeloid Leukemia When a Matched Related Donor Is Not Available Hematology, January 1, 2008; 2008(1): 412 - 417. [Abstract] [Full Text] [PDF]

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