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Blood, 1 January 2008, Vol. 111, No. 1, pp. 387-391. Prepublished online as a Blood First Edition Paper on October 16, 2007; DOI 10.1182/blood-2007-07-092015. This Article Full Text (PDF) All Versions of this Article: blood-2007-07-092015v1 111/1/387    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Russell, L. J Articles by Harrison, C. J. Search for Related Content PubMed PubMed Citation Articles by Russell, L. J Articles by Harrison, C. J. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted July 2, 2007 Accepted September 19, 2007 t(6;14)(p22;q32): a new recurrent IGH@ translocation involving ID4 in B-cell precursor acute lymphoblastic leukaemia (BCP-ALL) Lisa J Russell, Takashi Akasaka, Aneela Majid, Kei-ji Sugimoto, E. Loraine Karran, Inga Nagel, Lana Harder, Alexander Claviez, Stefan Gesk, Anthony V. Moorman, Fiona Ross, Helen Mazzullo, Jonathan C. Strefford, Reiner Siebert, Martin J.S. Dyer, and Christine J. Harrison* Leukaemia Research Cytogenetics, Cancer Sciences Division, University of Southampton, Southampton, United Kingdom Medical Research Council (MRC) Toxicology Unit, University of Leicester, Leicester, United Kingdom Institute of Human Genetics, University Hospital Schleswig-Holstein, Kiel, Germany Wessex Regional Genetics Laboratory, University of Southampton, Salisbury, United Kingdom Department of Haematology, University College Hospital, London, United Kingdom * Corresponding author; email: harrison{at}soton.ac.uk. Translocations involving the immunoglobulin heavy chain locus (IGH@) at chromosome band 14q32 are common in mature B-cell neoplasms, but are rare in B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Here, we report the translocation, t(6;14)(p22;q32), involving IGH@ as a novel recurrent translocation in 13 BCP-ALL patients. Fluorescence in situ hybridization and long-distance inverse polymerase chain reaction identified ID4 as the partner gene. Breakpoints were scattered over a 19kb region centromeric of ID4. Quantitative real-time PCR showed upregulation of ID4 mRNA. All patients had deletions of CDKN2A and PAX5 located on the short arm of chromosome 9, frequently as a result of an isochromosome, i(9)(q10) (9/13, 69%). This study defines a new subgroup of BCP-ALL characterized by ID4 over-expression and CDKN2A and PAX5 deletions. Preliminary survival data suggest that this subgroup may be associated with a good response to therapy. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: L. J. Russell, M. Capasso, I. Vater, T. Akasaka, O. A. Bernard, M. J. Calasanz, T. Chandrasekaran, E. Chapiro, S. Gesk, M. Griffiths, et al. Deregulated expression of cytokine receptor gene, CRLF2, is involved in lymphoid transformation in B-cell precursor acute lymphoblastic leukemia Blood, September 24, 2009; 114(13): 2688 - 2698. [Abstract] [Full Text] [PDF] S. Sulong, A. V. Moorman, J. A. E. Irving, J. C. Strefford, Z. J. Konn, M. C. Case, L. Minto, K. E. Barber, H. Parker, S. L. Wright, et al. A comprehensive analysis of the CDKN2A gene in childhood acute lymphoblastic leukemia reveals genomic deletion, copy number neutral loss of heterozygosity, and association with specific cytogenetic subgroups Blood, January 1, 2009; 113(1): 100 - 107. [Abstract] [Full Text] [PDF]

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