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Blood, 15 February 2008, Vol. 111, No. 4, pp. 2253-2260. Prepublished online as a Blood First Edition Paper on November 27, 2007; DOI 10.1182/blood-2007-07-098848. This Article Full Text (PDF) All Versions of this Article: blood-2007-07-098848v1 111/4/2253    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Traverse-Glehen, A. Articles by Felman, P. Search for Related Content PubMed PubMed Citation Articles by Traverse-Glehen, A. Articles by Felman, P. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted July 2, 2007 Accepted November 17, 2007 Splenic red pulp lymphoma with numerous basophilic villous lymphocytes: a distinct clinico-pathological and molecular entity? Alexandra Traverse-Glehen, Lucile Baseggio, Evelyne Callet-Bauchu, Dominique Morel, Sophie Gazzo, Martine Ffrench, Aurelie Verney, Delphine Rolland, Catherine Thieblemont, Jean-Pierre Magaud, Gilles Salles, Bertrand Coiffier, Francoise Berger, and Pascale Felman* Service d'Anatomie Pathologique Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, Lyon, France Laboratoire d'Hematologie Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, Lyon, France UMR CNRS 5239 Equipe "Pathologie des Cellules Lymphoides", Universite Lyon 1, Lyon, France Service d'Hematologie Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, Lyon, France * Corresponding author; email: pascale.felman{at}chu-lyon.fr. The presence of circulating villous lymphocytes (VL) in lymphoma patients usually points to splenic marginal zone B cell lymphoma (SMZL), even if they can be found occasionally in other small B-cell lymphomas. However those cells are variably described and detailed cytological characterization is often lacking. We identified lymphoma cases with numerous basophilic VL among the large group of splenic lymphoma with villous lymphocytes, and for further delineation, 37 cases with this particular cytology were analyzed. Patients, predominantly older males, presented with moderate lymphocytosis and splenomegaly without pancytopenia. The monoclonal B cells expressed IgM+D, IgM+G, IgM or IgG, as well as CD76 and CD11c, frequently CD103 and rarely CD123. Spleen sections were peculiar with atrophic white pulp and a monomorphic diffuse lymphoma infiltration in a congested red pulp. Bone marrow infiltration was interstitial and intrasinusoidal without extensive fibrosis. Cytogenetic analysis showed a frequent absence of clonal aberrations (68%). Most cases (79%) were IgH mutated with an over-representation of VH3 and VH4 gene families. These results, as well as the clinical evolution, show that those lymphoma cases represent a homogeneous group, distinct from SMZL and reminiscent of HCL-Variant, perhaps corresponding to a separate lymphoma entity. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: H. Y. Dong, J. Weisberger, Z. Liu, and S. Tugulea Immunophenotypic Analysis of CD103+ B-Lymphoproliferative Disorders: Hairy Cell Leukemia and Its Mimics Am J Clin Pathol, April 1, 2009; 131(4): 586 - 595. [Abstract] [Full Text] [PDF]

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