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Blood, 15 November 2007, Vol. 110, No. 10, pp. 3780-3783. Prepublished online as a Blood First Edition Paper on August 28, 2007; DOI 10.1182/blood-2007-07-100248. This Article Full Text (PDF) All Versions of this Article: blood-2007-07-100248v1 110/10/3780    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by De Domenico, I. Articles by Kaplan, J. Search for Related Content PubMed PubMed Citation Articles by De Domenico, I. Articles by Kaplan, J. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted July 9, 2007 Accepted August 22, 2007 Zebrafish as a model for defining the functional impact of mammalian ferroportin mutations Ivana De Domenico, Michael B Vaughn, Donghoon Yoon, James P. Kushner, Diane M Ward, and Jerry Kaplan* Department of Pathology, School of Medicine, University of Utah, Salt Lake City, UT Division of Hematology and Bone Marrow Transplantation, Department of Medicine, School of Medicine, University of Utah, Salt Lake City, UT * Corresponding author; email: jerry.kaplan{at}path.utah.edu. The term hemochromatosis represents a group of inherited disorders leading to iron overload. Mutations in HFE, HJV and TfR2 cause autosomal recessive forms of hemochromatosis. Mutations in Ferroportin, however, result in dominantly inherited iron overload. Some mutations (H32R, N174I) in ferroportin lead to macrophage iron loading while others (NI44H) lead to hepatocyte iron loading. Expression of H32R or N174I ferroportin cDNA in zebrafish leads to severe iron-limited erythropoiesis. Expression of wild type ferroportin or hepcidin resistant ferroportin (N144H) does not affect erythropoiesis. Zebrafish provides a facile way of identifying which ferroportin mutants may lead to macrophage iron loading. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: I. De Domenico, E. Lo, D. M. Ward, and J. Kaplan Hepcidin-induced internalization of ferroportin requires binding and cooperative interaction with Jak2 PNAS, March 10, 2009; 106(10): 3800 - 3805. [Abstract] [Full Text] [PDF]

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