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Blood, 15 January 2008, Vol. 111, No. 2, pp. 666-671. Prepublished online as a Blood First Edition Paper on October 1, 2007; DOI 10.1182/blood-2007-07-102665. This Article Full Text (PDF) Supplemental Appendix All Versions of this Article: blood-2007-07-102665v1 111/2/666    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Ruggeri, M. Articles by Barbui, T. Search for Related Content PubMed PubMed Citation Articles by Ruggeri, M. Articles by Barbui, T. Related Collections Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted July 24, 2007 Accepted September 26, 2007 Post-surgery outcomes in patients with polycythemia vera and essential thrombocythemia: a retrospective survey Marco Ruggeri, Francesco Rodeghiero*, Alberto Tosetto, Giancarlo Castaman, Francesca Scognamiglio, Guido Finazzi, Federica Delaini, Caterina Mico, Alessandro M. Vannucchi, Elisabetta Antonioli, Valerio De Stefano, Tommaso Za, Luigi Gugliotta, Alessia Tieghi, Maria Gabriella Mazzucconi, Cristina Santoro, and Tiziano Barbui Department of Hematology, San Bortolo Hospital, Vicenza, Italy Department of Hematology, Ospedali Riuniti di Bergamo, Bergamo, Italy Department of Hematology, University of Firenze, Firenze, Italy Institute of Hematology, Catholic University, Roma, Italy Service of Hematology, Santa Maria Nuova Hospital, Reggio Emilia, Italy Department of Biocellular Technology and Hematology, La Sapienza University, Roma, Italy * Corresponding author; email: rodeghiero{at}hemato.ven.it. A multicenter retrospective analysis was performed to estimate the frequency of thrombosis and haemorrhage after surgical procedures in patients with Polycythemia Vera (PV) and Essential Thrombocythemia (ET). Data from 105 PV and 150 ET patients were analyzed, for a total of 311 surgical interventions. An emergency procedure was performed in 25 (8.1%); 194 surgeries were done under general anaesthesia and 21/91 abdominal interventions (23%) under laparoscopy; 155 (50,1%) were major surgeries. Subcutaneous heparin was administered in 169/311 cases and antiplatelet therapy in 48/311 cases (54.3 and 15.4%, respectively) interventions. 188/255 (74%) were on cytoreductive therapy before surgery. No events were observed in 259/311 procedures (83.2%) during 3 months follow-up; there were 12 arterial and 12 venous thrombotic events, 23 major, 7 minor hemorrhages and 5 deaths. Arterial thrombosis were more frequent in ET (5.3 vs. 1.5%, P=0.08), venous events were more frequent in PV (7.7 vs. 1.1%, P=0.002). There was not a correlation between bleeding episodes and the type of diagnosis, use of antithrombotic prophylaxis or type of surgery. An high proportion of PV and ET surgeries was complicated by vascular occlusion (7.7%) or by a major hemorrhage (7.3%). Prospective investigations analyzing the optimal prophylaxis in these patients are suggested. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Steel to heal? MPD surgical conundrums Ruben A. Mesa Blood 2008 111: 474. [Full Text] [PDF]

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