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Blood, 15 January 2008, Vol. 111, No. 2, pp. 761-766. Prepublished online as a Blood First Edition Paper on October 29, 2007; DOI 10.1182/blood-2007-08-104877. This Article Full Text (PDF) All Versions of this Article: blood-2007-08-104877v1 111/2/761    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Haas, J. Articles by Wildemann, B. Search for Related Content PubMed PubMed Citation Articles by Haas, J. Articles by Wildemann, B. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted August 6, 2007 Accepted October 24, 2007 Specific recruitment of regulatory T-cells into the CSF in lymphomatous and carcinomatous meningitis Juergen Haas, Laila Schopp, Brigitte Storch-Hagenlocher, Benedikt Fritzsching, Christian Jacobi, Linda Milkova, Brigitte Fritz, Alexander Schwarz, Elisabeth Suri-Payer, Manfred Hensel, and Brigitte Wildemann* Division of Molecular Neuroimmunology, Dept of Neurology, University of Heidelberg, Heidelberg, Germany Dept of Neonatology, Children's Hospital, University of Heidelberg, Heidelberg, Germany Division of Immunogenetics/Tumorimmunology Program, German Cancer Research Center, Heidelberg, Germany Dept of Internal Medicine V, University of Heidelberg, Heidelberg, Germany * Corresponding author; email: brigitte_wildemann{at}med.uni-heidelberg.de. Whereas regulatory T-cells (Treg) play an important role in the prevention of autoimmunity increasing evidence suggests that their downregulatory properties negatively affect immune responses directed against tumors. Treg selectively express chemokine receptors CCR4 and CCR8 and specific migration occurs following the release of various chemokines. Neoplastic meningitis (NM) resulting from leptomeningeal spread of systemic non Hodgkin lymphoma (NHL) or carcinoma has a poor prognosis. We hypothesized that Treg accumulation within the subarachnoid space by interfering with tumor immunity may be relevant for survival of neoplastic cells. We collected CSF from 101 patients diagnosed with lymphomatous/carcinomatous NM and various inflammatory (ID) and non-inflammatory neurologic disorders (NID). CSF Treg-counts were determined by flow cytometry, Treg-specific chemokines by ELISA, and Treg-trafficking by chemotaxis assay. Both frequencies of Treg and Treg-specific chemotactic activities were significantly elevated in CSF samples of NM patients. Local Treg accumulation occurred without concomitant rise of Tconv, coincided with elevated concentrations of Treg-attracting chemokines CCL17 and CCL22 and correlated with numbers of atypical CSF cells. We conclude that Treg are specifically recruited into the CSF of NM patients, suggesting that the presence of Treg within the subarachnoid space generates a microenvironment which may favor survival and growth of malignant cells. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: A. W. Mailloux and M. R. I. Young NK-Dependent Increases in CCL22 Secretion Selectively Recruits Regulatory T Cells to the Tumor Microenvironment J. Immunol., March 1, 2009; 182(5): 2753 - 2765. [Abstract] [Full Text] [PDF]

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