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Blood, 1 March 2008, Vol. 111, No. 5, pp. 2521-2526.
Prepublished online as a Blood First Edition Paper on September 27, 2007; DOI 10.1182/blood-2007-08-104984.
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Submitted August 2, 2007
Accepted September 22, 2007
Recent major improvement in long-term survival
of younger patients with multiple myeloma
Hermann Brenner*, Adam Gondos, and Dianne Pulte
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
Weill Cornell Medical Center, New York, NY, United States
* Corresponding author; email: h.brenner{at}dkfz-heidelberg.de.
In the past, most patients with multiple myeloma (MM) died within 5-10 years following diagnosis. Within the past decade, several new therapeutic interventions have been introduced, including autologous stem cell transplant, thalidomide, lenalidomide, and bortezomib. We estimated trends in age specific 5- and 10-year relative survival of MM patients in the United States from 1990-1992 to 2002-2004 from the 1973-2004 database of the Surveillance, Epidemiology, and End Results (SEER) Program. Techniques of period analysis were employed to disclose most recent developments. Overall, 5-year relative survival increased from 28.8% to 34.7% (p<0.0001), and 10-year relative survival increased from 11.1% to 17.4% (p<0.0001) between 1990-92 and 2002-04. Much stronger increases were seen in age group <50, leading to 5- and 10-year relative survival of 56.7% and 41.3% in 2002-04, and in age group 50-59, leading to 5- and 10-year relative survival of 48.2% and 28.6% in 2002-2004. By contrast, only moderate improvement was seen in age group 60-69, and essentially no improvement was achieved among older patients. Our period analysis discloses a major increase in long-term survival of younger patients with MM in recent years which most likely reflects the impact of recent advances in therapy and their dissemination in clinical practice.
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