Blood online
Home About Blood Authors Subscriptions Permission Advertising Public Access contact us
 

 
Advanced
Current Issue
First Edition
Future Articles
Archives
Submit to Blood
Search
American Society of Hematology
Meeting Abstracts
Email Alerts
 Blood, 1 May 2008, Vol. 111, No. 9, pp. 4706-4715.
Prepublished online as a Blood First Edition Paper on February 22, 2008; DOI 10.1182/blood-2007-08-105643.

This Article
Right arrow Full Text (PDF)
Right arrow Supplemental Figures
Right arrow All Versions of this Article:
blood-2007-08-105643v1
111/9/4706    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Right arrow Rights and Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Scheeren, F. A
Right arrow Articles by Spits, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Scheeren, F. A
Right arrow Articles by Spits, H.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

arrow to previous article Previous Article  |  Next Article next article arrow

Submitted August 8, 2007
Accepted February 17, 2008

IL-21 is expressed in Hodgkin Lymphoma and activates STAT5; evidence that activated STAT5 is required for Hodgkin Lymphomagenesis

Ferenc A Scheeren, Sean A Diehl, Laura A Smit, Tim Beaumont, Marianne Naspetti, Richard J Bende, Bianca Blom, Kennosuke Karube, Koichi Ohshima, Carel J.M. van Noesel, and Hergen Spits*

Department of Cell Biology and Histology, Amsterdam Medical Center, University of Amsterdam, Amsterdam, Netherlands
Department of Pathology, Amsterdam Medical Center, University of Amsterdam, Amsterdam, Netherlands
AIMM Therapeutics, Amsterdam, Netherlands
Department of Pathology, Kurume University School of Medicine, Kurume, Japan

* Corresponding author; email: spits.hergen{at}gene.com.

Classical Hodgkin's Lymphoma (HL) is a malignant disorder characterized by the presence of neoplastic mono-nucleated Hodgkin and multi-nucleated Reed-Sternberg cells. Here, we show that both the IL-21 receptor as well as IL-21 are expressed by HL cells. IL-21 activates signal transducer of activation and transcription (STAT)-3 and 5 in HL cell lines and activated human B cells. Ectopic expression of constitutively active STAT5 in primary human B cells resulted in immortalized B cells that have lost the B cell phenotype and strongly resembled HL cells, which could partially be rescued by ectopic expression of the B cell-determining transcription factor E47. The data suggest that STAT5 is directly involved in HL genesis.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Am. J. Pathol.Home page
J. Dien Bard, P. Gelebart, M. Anand, Z. Zak, S. A. Hegazy, H. M. Amin, and R. Lai
IL-21 Contributes to JAK3/STAT3 Activation and Promotes Cell Growth in ALK-Positive Anaplastic Large Cell Lymphoma
Am. J. Pathol., August 1, 2009; 175(2): 825 - 834.
[Abstract] [Full Text] [PDF]


click for free articles
home about blood authors subscriptions permissions advertising public access contact us
  Copyright © 2008 by American Society of Hematology         Online ISSN: 1528-0020