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Blood, 1 May 2008, Vol. 111, No. 9, pp. 4463-4470. Prepublished online as a Blood First Edition Paper on February 21, 2008; DOI 10.1182/blood-2007-08-105759. This Article Full Text (PDF) Supplemental Appendix All Versions of this Article: blood-2007-08-105759v1 111/9/4463    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Mourad, N. Articles by Gaulard, P. Search for Related Content PubMed PubMed Citation Articles by Mourad, N. Articles by Gaulard, P. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted August 10, 2007 Accepted February 13, 2008 Clinical, biological and pathological features in 157 patients with angioimmunoblastic T-cell lymphoma treated within the Groupe d'Etude des Lymphomes de l'Adulte (GELA) trials Nathalie Mourad, Nicolas Mounier, Josette Briere, Emmanuel Raffoux, Alain Delmer, Alfred Feller, Chris JLM Meijer, Jean-Francois Emile, Reda Bouabdallah, Andre Bosly, Jacques Diebold, Corinne Haioun, Bertrand Coiffier, Christian Gisselbrecht, and Philippe Gaulard* Service de Pathologie, Inserm, U728, Universite Paris 7, AP-HP, Hopital Saint Louis, Paris, France Service de Cancerlogie, CHU de Nice l'Archet, Clinique Universitaire des Specialites Medicales, Nice, France Service d'Hematologie adulte, Hopital Saint Louis, Paris, France Service d'Hematologie, Hopital Robert Debre, Reims, France Institute for Pathology, University Clinic of Schleswig-Holstein (UK-SH), Campus Lubeck, Lubeck, Germany Department of Pathology, Vrije Universiteit Medical Center, Amsterdam, Netherlands Service de Pathologie, Hopital Ambroise Pare, APHP et Faculte de MEdecine PIFO, UVSQ, Boulogne, France Service d'Hematologie, Institut Paoli-Calmettes, Marseille, France Service d'Hematologie, Universite Catholique de Louvain, Yvoir, Belgium Service d'Anatomie Pathologique, Hopital Hotel Dieu, Paris, France Service d'Hematologie, Hopital Henri Mondor, Creteil, France Service d'Hematologie, CH Lyon Sud, Pierre Benite, France Service d'Hematologie, Inserm, U728, Universite Paris 7, AP-HP, Hopital Saint Louis, Paris, France Departement de Pathologie, Inserm U481, Universite Paris 12, Faculte de medecine, AP-HP, Hopital Henri MOndor, Creteil, France * Corresponding author; email: philippe.gaulard{at}hmn.aphp.fr. To evaluate the prognostic significance of clinico-biological and pathological features in angioimmunoblastic T-cell lymphoma (AITL), 157 patients with AITL were retrieved from the GELA LNH87-LNH93 randomized clinical trials. 147 patients received a CHOP-like regimen with intensified courses in half of them. Histologically, 41 cases were classified as "rich in large cells" and 116 as "classic" (including 19 rich in epithelioid cells, 14 rich in clear cells, and 4 with hyperplastic germinal centers). 62 cases were evaluated for CD10 and CXCL13 expression and scored according to the abundance of positive lymphoid cells. Median age was 62y with 81% advanced stage, 72% B symptoms, 65% anemia, 50% hypergammaglobulinemia and 66% elevated LDH. Overall 7y survival was 30%. In multivariate analysis, only male gender (p=0.004), mediastinal lymphadenopathy (p=0.041) and anemia (p=0.042)adversely affected overall survival. The increase in large cells and high scoring level of CD10 and CXCL13 (72%) did not affect survival. Intensive regimen did not improve survival. In conclusion, AITL is a morphologically heterogeneous T-cell lymphoma commonly expressing CXCL13 and CD10 and carrying few prognostic factors. It portends a poor prognosis even when treated intensively. However, not always lethal as 30% of patients are alive at 7 years. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: J. S. Abramson, S. Digumarthy, and J. A. Ferry Case 27-2009 -- A 56-Year-Old Woman with Fever, Rash, and Lymphadenopathy N. Engl. J. Med., August 27, 2009; 361(9): 900 - 911. [Full Text] [PDF] C. Kyriakou, C. Canals, J. Finke, G. Kobbe, J.-L. Harousseau, H.-J. Kolb, N. Novitzky, A. H. Goldstone, A. Sureda, and N. Schmitz Allogeneic Stem Cell Transplantation Is Able to Induce Long-Term Remissions in Angioimmunoblastic T-Cell Lymphoma: A Retrospective Study From the Lymphoma Working Party of the European Group for Blood and Marrow Transplantation J. Clin. Oncol., August 20, 2009; 27(24): 3951 - 3958. [Abstract] [Full Text] [PDF] L. de Leval and P. Gaulard Pathobiology and Molecular Profiling of Peripheral T-Cell Lymphomas Hematology, January 1, 2008; 2008(1): 272 - 279. [Abstract] [Full Text] [PDF] K. J. Savage Prognosis and Primary Therapy in Peripheral T-Cell Lymphomas Hematology, January 1, 2008; 2008(1): 280 - 288. [Abstract] [Full Text] [PDF]

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