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Blood, 15 March 2008, Vol. 111, No. 6, pp. 3108-3115. Prepublished online as a Blood First Edition Paper on January 10, 2008; DOI 10.1182/blood-2007-08-105965. This Article Full Text (PDF) Supplemental Table and Figures Additional Supplemental Figures All Versions of this Article: blood-2007-08-105965v1 111/6/3108    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Carlino, C. Articles by Gismondi, A. Search for Related Content PubMed PubMed Citation Articles by Carlino, C. Articles by Gismondi, A. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted August 7, 2007 Accepted January 6, 2008 Recruitment of circulating NK cells through decidual tissues: a possible mechanism controlling NK cell accumulation in the uterus during early pregnancy Claudia Carlino, Helena Stabile, Stefania Morrone, Roberta Bulla, Alessandra Soriani, Chiara Agostinis, Fleur Bossi, Carlo Mocci, Filippo Sarazani, Francesco Tedesco, Angela Santoni, and Angela Gismondi* Department of Experimental Medicine, University of Rome "La Sapienza", Rome, Italy Department of Gynecology, University of Rome "La Sapienza", Rome, Italy Department of Physiology and Pathology, University of Trieste, Trieste, Italy * Corresponding author; email: angela.gismondi{at}uniroma1.it. During early pregnancy, uterine mucosa decidualization is accompanied by a drastical enrichment of CD56highCD16negative NK cells. Decidual NK (dNK) cells differ from peripheral blood NK (pbNK) cells in several ways, but their origin is still unclear. Our results demonstrate that chemokines present in the uterus can support pbNK cell migration through human endothelial and stromal decidual cells. Notably, we observed that pregnant women pbNK cells are endowed with higher migratory ability with respect to non-pregnant women or male donor pbNK cells. Moreover, NK cell migration through decidual stromal cells was increased when progesterone-cultured stromal cells were used as substrate, and this correlated with the ability of progesterone to up-regulate stromal cell chemokine expression. Furthermore, we demonstrate that also dNK cells can migrate through stromal cells using a distinct pattern of chemokines. Finally, we found that pbNK cells acquire a chemokine receptor pattern very similar to that of dNK cells when contact decidual stromal cells. Collectively these results strongly suggest that pbNK cell recruitment to the uterus contributes to the accumulation of NK cells during early pregnancy; that progesterone plays a crucial role in this event; and that pbNK cells undergo reprogramming their chemokine receptor profile once exposed to uterine microenvironment. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

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