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Blood, 1 April 2008, Vol. 111, No. 7, pp. 3626-3634. Prepublished online as a Blood First Edition Paper on January 28, 2008; DOI 10.1182/blood-2007-08-106203.
Submitted August 10, 2007
Department of Experimental Medicine, Istituto Pasteur, Fondazione Cenci Bolognetti, University of Rome "La Sapienza", Rome, Italy * Corresponding author; email: giovanni.bernardini{at}uniroma1.it.
Herein we have analyzed chemokine involvement in the trafficking of developing and mature mouse NK cells in the bone marrow (BM). We observed drastic changes of CCR1, CXCR3 and CXCR4 expression and function during progression from NK cell precursors (pNK) to immature DX5- (iNK) and mature DX5+ (mNK) NK cells. pNK and mNK cells expressed the three receptors, while only CXCR4 was detected on iNK cells. Correspondingly, mNK cells migrated to CXCL12, CXCL10 and CCL3, and pNK and iNK cells to CXCL12, whereas pNK cells migrated to CCL3 and CXCL10 only after CXCL12 stimulation.
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