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Blood, 15 June 2008, Vol. 111, No. 12, pp. 5524-5529. Prepublished online as a Blood First Edition Paper on April 18, 2008; DOI 10.1182/blood-2007-08-109611. This Article Full Text (PDF) All Versions of this Article: blood-2007-08-109611v1 111/12/5524    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Schollkopf, C. Articles by Hjalgrim, H. Search for Related Content PubMed PubMed Citation Articles by Schollkopf, C. Articles by Hjalgrim, H. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted August 27, 2007 Accepted March 19, 2008 Borrelia infection and risk of non-Hodgkin lymphoma Claudia Schollkopf*, Mads Melbye, Lars Munksgaard, Karin Ekstrom Smedby, Klaus Rostgaard, Bengt Glimelius, Ellen T. Chang, Goran Roos, Mads Hansen, Hans-Olov Adami, and Henrik Hjalgrim Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark Department of Hematology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden Dep. of Pathology and Oncology, Karolinska Institutet, Stockholm, Sweden Department of Health Research and Policy, Stanford University School of Medicine, Stanford, California, United States Department of Pathology, Norrlands University Hospital, Umeå, Sweden Department of Epidemiology, Harvard School of Public Health, Boston, United States * Corresponding author; email: cko{at}ssi.dk. Reports of the presence of Borrelia (B.) burgdorferi DNA in malignant lymphomas have raised the hypothesis that infection with B. burgdorferi may be causally related to non-Hodgkin lymphoma (NHL) development. We conducted a Danish-Swedish case-control study including 3,055 NHL patients and 3,187 population controls. History of tick bite or Borrelia infection was ascertained through structured telephone interviews and through enzyme-linked immunosorbent assay serum analyses for antibodies against B. burgdorferi in a subset of 1579 patients and 1354 controls. Statistical associations with risk of NHL, including histological subtypes, were assessed by lo-gistic regression. Overall risk of NHL was not associated with self-reported history of tick bite (odds ratio (OR) =1.0; 95% confidence interval 0.9-1.1), Bor-relia infection (OR=1.3 (0.96-1.8)) or the presence of anti-Borrelia antibodies (OR=1.3 (0.9-2.0)). However, in analyses of NHL subtypes, self-reported history of B. burgdorferi infection (OR=2.5 (1.2-5.1)) and seropositivity for anti-Borrelia antibodies (OR=3.6 (1.8-7.4)) were both associated with risk of mantle cell lymphoma. Convincingly, this specific association was also observed in persons who did not recall Borrelia infection yet tested positive for anti-Borrelia antibodies (OR=4.2 (2.0-8.9)). Our observations suggest a previously unreported association between B. burgdorferi infection and risk of mantle cell lymphoma. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

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