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Blood, 1 February 2008, Vol. 111, No. 3, pp. 1004-1012. Prepublished online as a Blood First Edition Paper on October 17, 2007; DOI 10.1182/blood-2007-09-110874. This Article Full Text (PDF) Supplemental Methods and Figures All Versions of this Article: blood-2007-09-110874v1 111/3/1004    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Bossen, C. Articles by Schneider, P. Search for Related Content PubMed PubMed Citation Articles by Bossen, C. Articles by Schneider, P. Related Collections Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted September 7, 2007 Accepted October 5, 2007 TACI, unlike BAFF-R, is solely activated by oligomeric BAFF and APRIL to support survival of activated B cells and plasmablasts Claudia Bossen, Teresa G Cachero, Aubry Tardivel, Karine Ingold, Laure Willen, Max Dobles, Martin L Scott, Aris Maquelin, Elodie Belnoue, Claire-Anne Siegrist, Stephane Chevrier, Hans Acha-Orbea, Helen Leung, Fabienne Mackay, Jurg Tschopp, and Pascal Schneider* Department of Biochemistry, University of Lausanne, Epalinges, Switzerland BiogenIdec, Cambridge, MA, United States Department of Pathology-Immunology and Pediatrics, University of Geneva, Geneva, Switzerland Garvan Institute of Medical Research, Darlinghurst, Australia * Corresponding author; email: pascal.schneider{at}unil.ch. The cytokine BAFF binds to the receptors TACI, BCMA and BAFF-R on B cells, whereas APRIL binds to TACI and BCMA only. The signaling properties of soluble trimeric BAFF (BAFF 3-mer) were compared to those of higher order BAFF oligomers. All forms of BAFF bound BAFF-R and TACI,and elicited BAFF-R-dependent signals in primary B cells. In contrast, signaling through TACI in mature B cells or plasmablasts was only achieved by higher order BAFF andAPRIL oligomers, all of which were also potent activators of a multimerizationdependent reporter signaling pathway. These results indicate that although BAFF-R andTACI can provide B cells with similar signals, only BAFF-R, but not TACI, can respond to soluble BAFF 3-mer, which is the main form of BAFF found in circulation. BAFF 60-mer, an efficient TACI agonist, was also detected in plasma of BAFF transgenic and nontransgenic mice and was greater than 100-fold more active than BAFF 3-mer for the activation of multimerization-dependent signals. TACI supported survival of activated B cells and plasmablasts in vitro, providing a rational basis to explain the immunoglobulindeficiency reported in TACI-deficient individuals. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Different partners in different places? Michael P. Cancro Blood 2008 111: 975. [Full Text] [PDF] This article has been cited by other articles: J. J. Lee, I. Rauter, L. Garibyan, E. Ozcan, T. Sannikova, S. R. Dillon, A. C. Cruz, R. M. Siegel, R. Bram, H. Jabara, et al. The murine equivalent of the A181E TACI mutation associated with common variable immunodeficiency severely impairs B-cell function Blood, September 10, 2009; 114(11): 2254 - 2262. [Abstract] [Full Text] [PDF] A. Wyzgol, N. Muller, A. Fick, S. Munkel, G. U. Grigoleit, K. Pfizenmaier, and H. Wajant Trimer Stabilization, Oligomerization, and Antibody-Mediated Cell Surface Immobilization Improve the Activity of Soluble Trimers of CD27L, CD40L, 41BBL, and Glucocorticoid-Induced TNF Receptor Ligand J. Immunol., August 1, 2009; 183(3): 1851 - 1861. [Abstract] [Full Text] [PDF] C. Tertilt, J. Joh, A. Krause, P. Chou, K. Schneeweiss, R. G. Crystal, and S. Worgall Expression of B-Cell Activating Factor Enhances Protective Immunity of a Vaccine against Pseudomonas aeruginosa Infect. Immun., July 1, 2009; 77(7): 3044 - 3055. [Abstract] [Full Text] [PDF] U. Salzer, C. Bacchelli, S. Buckridge, Q. Pan-Hammarstrom, S. Jennings, V. Lougaris, A. Bergbreiter, T. Hagena, J. Birmelin, A. Plebani, et al. Relevance of biallelic versus monoallelic TNFRSF13B mutations in distinguishing disease-causing from risk-increasing TNFRSF13B variants in antibody deficiency syndromes Blood, February 26, 2009; 113(9): 1967 - 1976. [Abstract] [Full Text] [PDF] E. Mohr, K. Serre, R. A. Manz, A. F. Cunningham, M. Khan, D. L. Hardie, R. Bird, and I. C. M. MacLennan Dendritic Cells and Monocyte/Macrophages That Create the IL-6/APRIL-Rich Lymph Node Microenvironments Where Plasmablasts Mature J. Immunol., February 15, 2009; 182(4): 2113 - 2123. [Abstract] [Full Text] [PDF]

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