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Blood, 1 March 2008, Vol. 111, No. 5, pp. 2919-2928. Prepublished online as a Blood First Edition Paper on November 7, 2007; DOI 10.1182/blood-2007-09-112789. This Article Full Text (PDF) Supplemental Figures All Versions of this Article: blood-2007-09-112789v1 111/5/2919    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Beilhack, A. Articles by Negrin, R. S Search for Related Content PubMed PubMed Citation Articles by Beilhack, A. Articles by Negrin, R. S Related Collections Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted September 25, 2007 Accepted October 23, 2007 Prevention of acute graft-versus-host disease by blocking T-cell entry to secondary lymphoid organs Andreas Beilhack, Stephan Schulz, Jeanette Baker, Georg F. Beilhack, Ryosei Nishimura, Enosh M. Baker, Gilad Landan, Edward I. Herman, Eugene C. Butcher, Christopher H. Contag, and Robert S Negrin* Department of Medicine, Stanford University, Stanford, CA, United States Department of Pathology, Technical University Munich, Munich, Germany Department of Pathology, Stanford University, Stanford, CA, United States Department of Pediatrics, Stanford University, Stanford, CA, United States * Corresponding author; email: negrs{at}stanford.edu. In acute graft-versus-host disease (aGVHD) donor T-cells attack the recipient's gastrointestinal tract, liver and skin. We hypothesized, that blocking access to distinct lymphoid priming sites may alter the specific organ tropism and prevent aGVHD development. In support of this initial hypothesis, we found that different secondary lymphoid organs (SLOs) imprint distinct homing receptor phenotypes on evolving alloreactive effector T-cells in vivo. Yet, preventing T-cell entry to specific SLOs through blocking monoclonal antibodies, or SLO ablation, did not alter aGVHD pathophysiology. Moreover, transfer of alloreactive effector T-cells into conditioned secondary recipients targeted the intestines and liver, irrespective of their initial priming site. Thus, we demonstrate redundancy of SLOs at different anatomical sites in aGVHD initiation. Only prevention of T-cell entry to all SLOs could completely abrogate the onset of aGVHD. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Bad news for GVHD prevention Andrea Bacigalupo Blood 2008 111: 2499-2500. [Full Text] [PDF] This article has been cited by other articles: B. E. Anderson, P. A. Taylor, J. M. McNiff, D. Jain, A. J. Demetris, A. Panoskaltsis-Mortari, A. Ager, B. R. Blazar, W. D. Shlomchik, and M. J. Shlomchik Effects of donor T-cell trafficking and priming site on graft-versus-host disease induction by naive and memory phenotype CD4 T cells Blood, May 15, 2008; 111(10): 5242 - 5251. [Abstract] [Full Text] [PDF] M. Stelljes, S. Hermann, J. Albring, G. Kohler, M. Loffler, C. Franzius, C. Poremba, V. Schlosser, S. Volkmann, C. Opitz, et al. Clinical molecular imaging in intestinal graft-versus-host disease: mapping of disease activity, prediction, and monitoring of treatment efficiency by positron emission tomography Blood, March 1, 2008; 111(5): 2909 - 2918. [Abstract] [Full Text] [PDF] T. D. Kim, T. H. Terwey, J. L. Zakrzewski, D. Suh, A. A. Kochman, M. E. Chen, C. G. King, C. Borsotti, J. Grubin, O. M. Smith, et al. Organ-derived dendritic cells have differential effects on alloreactive T cells Blood, March 1, 2008; 111(5): 2929 - 2940. [Abstract] [Full Text] [PDF]

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