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Blood, 15 February 2008, Vol. 111, No. 4, pp. 2470-2475. Prepublished online as a Blood First Edition Paper on November 27, 2007; DOI 10.1182/blood-2007-09-112987. This Article Full Text (PDF) Supplemental Tables and Figure All Versions of this Article: blood-2007-09-112987v1 111/4/2470    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Levine, J. E Articles by Ferrara, J. L.M. Search for Related Content PubMed PubMed Citation Articles by Levine, J. E Articles by Ferrara, J. L.M. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted September 14, 2007 Accepted November 21, 2007 Etanercept plus methylprednisolone as initial therapy for acute GVHD John E Levine*, Sophie Paczesny, Shin Mineishi, Thomas Braun, Sung W Choi, Raymond J Hutchinson, Dawn Jones, Yasser Khaled, Carrie L Kitko, Daniel Bickley, Oleg Krijanovski, Pavan Reddy, Gregory Yanik, and James L.M. Ferrara Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, United States Blood and Marrow Transplantation Program, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI, United States Department of Medicine, University of Michigan Medical School, Ann Arbor, MI, United States Department of Biostatistics, School o f Public Health, University of Michigan, Ann Arbor, MI, United States * Corresponding author; email: jelevine{at}umich.edu. Graft-versus-host disease (GVHD) is a principal cause of morbidity following allogeneic hematopoietic cell transplantation (HCT). Standard therapy for GVHD, high dose steroids, results in complete responses (CRs) in 35% of patients. Because tumor necrosis factor- (TNF) is an important effector of experimental GVHD, we treated patients with new onset GVHD with steroids plus the TNF inhibitor etanercept on a previously reported pilot trial (n=20) and a phase II trial (n=41). We compared their outcomes to those of contemporaneous patients with GVHD (n = 99) whose initial therapy was steroids alone. Groups were similar with respect to age, conditioning, donor, degree of HLA-match, and severity of GVHD at onset. Patients treated with etanercept were more likely to achieve CR than were patients treated with steroids alone (69% vs 33%, p<0.0001). This difference was observed in HCT recipients of both related donors (79% vs 39%, p=0.001) and unrelated donors (53% vs 26%, p=0.0005). Plasma TNFR1 levels, a biomarker for GVHD activity, were elevated at GVHD onset and decreased significantly only in patients with CR. We conclude that etanercept plus steroids as initial therapy for acute GVHD results in a substantial majority of CRs. This trial was referenced at www.clinicaltrials.gov as NCT00141713. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: G. Socie and B. R. Blazar Acute graft-versus-host disease: from the bench to the bedside Blood, November 12, 2009; 114(20): 4327 - 4336. [Abstract] [Full Text] [PDF] A. M. Alousi, D. J. Weisdorf, B. R. Logan, J. Bolanos-Meade, S. Carter, N. DiFronzo, M. Pasquini, S. C. Goldstein, V. T. Ho, B. Hayes-Lattin, et al. Etanercept, mycophenolate, denileukin, or pentostatin plus corticosteroids for acute graft-versus-host disease: a randomized phase 2 trial from the Blood and Marrow Transplant Clinical Trials Network Blood, July 16, 2009; 114(3): 511 - 517. [Abstract] [Full Text] [PDF] G. Yanik and K. Cooke Response: Etanercept for idiopathic pneumonia syndrome Blood, March 19, 2009; 113(12): 2869 - 2869. [Full Text] [PDF] S. Paczesny, O. I. Krijanovski, T. M. Braun, S. W. Choi, S. G. Clouthier, R. Kuick, D. E. Misek, K. R. Cooke, C. L. Kitko, A. Weyand, et al. A biomarker panel for acute graft-versus-host disease Blood, January 8, 2009; 113(2): 273 - 278. [Abstract] [Full Text] [PDF] G. A. Yanik, V. T. Ho, J. E. Levine, E. S. White, T. Braun, J. H. Antin, J. Whitfield, J. Custer, D. Jones, J. L. M. Ferrara, et al. The impact of soluble tumor necrosis factor receptor etanercept on the treatment of idiopathic pneumonia syndrome after allogeneic hematopoietic stem cell transplantation Blood, October 15, 2008; 112(8): 3073 - 3081. [Abstract] [Full Text] [PDF] S. W. Choi, C. L. Kitko, T. Braun, S. Paczesny, G. Yanik, S. Mineishi, O. Krijanovski, D. Jones, J. Whitfield, K. Cooke, et al. Change in plasma tumor necrosis factor receptor 1 levels in the first week after myeloablative allogeneic transplantation correlates with severity and incidence of GVHD and survival Blood, August 15, 2008; 112(4): 1539 - 1542. [Abstract] [Full Text] [PDF]

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