SEARCH:   Advanced

Blood, 15 August 2008, Vol. 112, No. 4, pp. 1249-1258. Prepublished online as a Blood First Edition Paper on June 6, 2008; DOI 10.1182/blood-2007-09-114389. This Article Full Text (PDF) Supplemental Figures All Versions of this Article: blood-2007-09-114389v1 112/4/1249    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Helft, J. Articles by Lantz, O. Search for Related Content PubMed PubMed Citation Articles by Helft, J. Articles by Lantz, O. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted September 24, 2007 Accepted May 9, 2008 Antigen specific T-T interactions regulate CD4 T cell expansion Julie Helft, Alexandra Jacquet, Nathalie Joncker, Isabelle Grandjean, Guillaume Dorothee, Adrien Kissenpfennig, Bernard Malissen, Polly Matzinger, and Olivier Lantz* Laboratoire d'Immunologie clinique, Institut Curie, Paris, France Inserm U653, Institut Curie, Paris, France Centre d'Immunologie de Marseille-Luminy, Marseille, France CNRS, UMR6102, Marseille, France The Ghost Lab, LCMI, NIAID, National Institutes of Health, Bethesda, MD, United States * Corresponding author; email: olivier.lantz{at}curie.net. The regulation of CD4 T cell numbers during an immune response should take account of the amount of antigen (Ag), the initial frequency of Ag-specific T cells, the mix of naive versus experienced cells, and (ideally) the diversity of the repertoire. Here we describe a novel mechanism of T cell regulation that potentially deals with all of these parameters. We found that CD4 T cells establish a negative feedback loop by capturing their cognate MHC/peptide complexes from Ag-presenting cells and presenting them to Ag-experienced CD4 T cells, thereby inhibiting their recruitment into the response while allowing recruitment of naive T cells. The inhibition is Ag specific, begins at day 2 (long before Ag disappearance), and cannot be overcome by providing new Ag-loaded dendritic cells. In this way CD4 T cell proliferation is regulated in a functional relationship to the amount of Ag, while allowing naive T cells to generate repertoire variety. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: E. N. M. Nolte-'t Hoen, S. I. Buschow, S. M. Anderton, W. Stoorvogel, and M. H. M. Wauben Activated T cells recruit exosomes secreted by dendritic cells via LFA-1 Blood, February 26, 2009; 113(9): 1977 - 1981. [Abstract] [Full Text] [PDF] W. F. N. Chan, H. Razavy, and C. C. Anderson Differential Susceptibility of Allogeneic Targets to Indirect CD4 Immunity Generates Split Tolerance J. Immunol., October 1, 2008; 181(7): 4603 - 4612. [Abstract] [Full Text] [PDF]

	Copyright © 2008 by American Society of Hematology         Online ISSN: 1528-0020