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Blood, 15 March 2008, Vol. 111, No. 6, pp. 2977-2983. Prepublished online as a Blood First Edition Paper on December 20, 2007; DOI 10.1182/blood-2007-10-115493. This Article Full Text (PDF) All Versions of this Article: blood-2007-10-115493v1 111/6/2977    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Brenner, H. Articles by Pulte, D. Search for Related Content PubMed PubMed Citation Articles by Brenner, H. Articles by Pulte, D. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted October 1, 2007 Accepted December 13, 2007 Ongoing improvement in long-term survival of patients with Hodgkin's disease at all ages and recent catch-up of older patients Hermann Brenner*, Adam Gondos, and Dianne Pulte Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany Weill Cornell Medical Center, New York, NY, United States * Corresponding author; email: h.brenner{at}dkfz-heidelberg.de. Since the breakthroughs in combination chemotherapy of patients with Hodgkin's disease (HD) starting in the 1960s, prognosis of patients has been rising steadily. Trends in long-term survival of patients with HD on the population level should therefore be monitored in an as timely as possible manner. We assessed trends in age specific 5- and 10-year relative survival of patients with HD in the United States from 1980-1984 to 2000-2004 from the 1973-2004 data base of the Surveillance, Epidemiology, and End Results (SEER) Program. Period analysis was employed to disclose recent developments with minimum delay. Overall, 5-year relative survival steadily increased from 73.5% to 85.2% (+11.7 percent units), and 10-year relative survival increased from 62.1% to 80.1% (+18.0 percent units) between 1980-84 and 2000-04, according to period analysis. The increase was particularly pronounced for age groups 45-59 and 60+ (increases in 10-year relative survival by 24.8 and 23.3 percentage points, respectively). Nevertheless, a strong age gradient persisted, with 10-year relative survival of 92.7%, 88.7%, 84.9%, 76.2% and 44.9% in age groups 15-24, 25-34, 35-44, 45-54, and 60+, respectively, in 2000-2004. Our period analysis discloses ongoing, major improvement in long-term survival of patients with HD in recent years, particularly among older patients. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: H. Brenner, A. Gondos, and D. Pulte Survival Expectations of Patients Diagnosed with Hodgkin's Lymphoma in 2006-2010 Oncologist, August 1, 2009; 14(8): 806 - 813. [Abstract] [Full Text] [PDF] Hodgkin Lymphoma Survival: Continuing Improvement Journal Watch Oncology and Hematology, April 15, 2008; 2008(415): 5 - 5. [Full Text]

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