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Blood, 15 April 2008, Vol. 111, No. 8, pp. 3986-3990. Prepublished online as a Blood First Edition Paper on January 2, 2008; DOI 10.1182/blood-2007-10-115659. This Article Full Text (PDF) All Versions of this Article: blood-2007-10-115659v1 111/8/3986    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Bower, M Articles by Powles, T Search for Related Content PubMed PubMed Citation Articles by Bower, M Articles by Powles, T Related Collections Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted October 1, 2007 Accepted November 27, 2007 Immunological recovery in survivors following chemotherapy for AIDS related non Hodgkin's lymphoma M Bower*, J Stebbing, M Tuthill, V Campbell, J Krell, P Holmes, A Ozzard, M Nelson, B Gazzard, and T Powles Department of Oncology, Imperial College School of Medicine, London, United Kingdom Department of HIV Medicine, Imperial College School of Medicine, London, United Kingdom Department of Oncology, St Bartholomew's Hospital, London, United Kingdom * Corresponding author; email: m.bower{at}imperial.ac.uk. Purpose Late effects of chemotherapy on immunological parameters in AIDS-related NHL have not been described. Patients and Methods From a cohort of 105 consecutive patients treated with infusional chemotherapy and HAART, 68 survived more than 3 months following the end of chemotherapy. Their lymphocyte subsets and plasma HIV viral loads were measured at regular intervals for 2 years and values compared to baseline. Results During chemotherapy, there were statistically significant falls in CD4 (helper T), CD8 (cytotoxic T) and CD19 (B) cell populations but no changes in the CD56 (natural killer) cell population. Amongst the 68 survivors, there were statistically significant increases in CD4, CD8, CD19 and CD56 cell populations during the first year of follow-up, compared to the values at the start of chemotherapy. During the second year of follow up there were further statistically significant rises in CD4 and CD19 cell populations, compared to the values at 12 months post chemotherapy. During 244 years of follow-up following chemotherapy in these 68 survivors, 7 second primary tumours and 8 opportunistic infections were diagnosed. Conclusion Chemotherapy and concomitant HAART for AIDS-related NHL does not cause prolonged suppression of lymphocyte subsets. These data should provide reassurance regarding the long term consequences of chemotherapy in these individuals. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: AIDS, T cells, chemotherapy: HAART-breaking? Richard F. Little Blood 2008 111: 3921-3922. [Full Text] [PDF] This article has been cited by other articles: A. Re, M. Michieli, S. Casari, B. Allione, C. Cattaneo, M. Rupolo, M. Spina, R. Manuele, E. Vaccher, M. Mazzucato, et al. High-dose therapy and autologous peripheral blood stem cell transplantation as salvage treatment for AIDS-related lymphoma: long-term results of the Italian Cooperative Group on AIDS and Tumors (GICAT) study with analysis of prognostic factors Blood, August 13, 2009; 114(7): 1306 - 1313. [Abstract] [Full Text] [PDF] L. Lin, J. Y. Lee, L. D. Kaplan, B. J. Dezube, A. Noy, S. E. Krown, A. M. Levine, Y. Yu, G. S. Hayward, and R. F. Ambinder Effects of Chemotherapy in AIDS-Associated Non-Hodgkin's Lymphoma on Kaposi's Sarcoma Herpesvirus DNA in Blood J. Clin. Oncol., May 20, 2009; 27(15): 2496 - 2502. [Abstract] [Full Text] [PDF]

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