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Blood, 15 June 2008, Vol. 111, No. 12, pp. 5683-5690. Prepublished online as a Blood First Edition Paper on April 7, 2008; DOI 10.1182/blood-2007-10-118794. This Article Full Text (PDF) All Versions of this Article: blood-2007-10-118794v1 111/12/5683    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Wlodarska, I. Articles by De Wolf-Peeters, C. Search for Related Content PubMed PubMed Citation Articles by Wlodarska, I. Articles by De Wolf-Peeters, C. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted October 18, 2007 Accepted March 30, 2008 Translocations targeting CCND2, CCND3 and MYCN do occur in t(11;14)-negative mantle cell lymphomas Iwona Wlodarska*, Daan Dierickx, Vera Vanhentenrijk, Katrien Van Roosbroeck, Helena Pospisilova, Francesca Minnei, Gregor Verhoef, Jose Thomas, Peter Vandenberghe, and Chris De Wolf-Peeters Center for Human Genetics, Katholieke Universiteit Leuven, Leuven, Belgium Department of Hematology, Katholieke Universiteit Leuven, Leuven, Belgium Department of Pathology, Katholieke Universiteit Leuven, Leuven, Belgium Department of Pathlogy, Katholieke Universiteit Leuven, Leuven, Belgium * Corresponding author; email: iwona.wlodarska{at}uz.kuleuven.ac.be. The genetics of t(11;14)(q13;q32)/cyclin D1-negative mantle cell lymphoma (MCL) is poorly understood. We report here eight MCL cases lacking t(11;14) or variant CCND1 rearrangement that showed expression of cyclin D1 (two cases), D2 (two cases) and D3 (three cases). One case was cyclin D-negative. Cytogenetics and fluorescence in situ hybridization detected t(2;12)(p11;p13)/IGK-CCND2 in one of the cyclin D2-positive cases and t(6;14)(p21;q32)/IGH-CCND3 in one of the cyclin D3-positive cases. Moreover, we identified a novel cryptic t(2;14)(p24;q32) targeting MYCN in two blastoid MCLs: one negative for cyclin D and one expressing cyclin D3. Interestingly, both cases revealed expression of cyclin E. Notably, all three blastoid MCLs showed a monoallelic deletion of RB1 associated with a lack of expression of RB1 protein, and monoallelic loss of p16. In summary, this study confirms frequent aberrant expression of cyclin D2 and D3 in t(11;14)-negative MCLs and demonstrates a t(11;14)-independent expression of cyclin D1 in 25% of present cases. Novel findings include cyclin E expression in two t(11;14)-negative MCLs characterized by a cryptic t(2;14)(p24;q32) and identification of MYCN as a new lymphoma oncogene associated with a blastoid MCL. Clinically important is a predisposition of t(11;14)-negative MCLs to the central nervous system involvement. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: A. Mozos, C. Royo, E. Hartmann, D. De Jong, C. Baro, A. Valera, K. Fu, D. D. Weisenburger, J. Delabie, S.-S. Chuang, et al. SOX11 expression is highly specific for mantle cell lymphoma and identifies the cyclin D1-negative subtype Haematologica, November 1, 2009; 94(11): 1555 - 1562. [Abstract] [Full Text] [PDF] L Stefancikova, M Moulis, P Fabian, I Falkova, I Vasova, L Kren, J Macak, and J Smardova Complex analysis of cyclin D1 expression in mantle cell lymphoma: two cyclin D1-negative cases detected J. Clin. Pathol., October 1, 2009; 62(10): 948 - 950. [Abstract] [Full Text] [PDF]

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