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Blood, 1 April 2008, Vol. 111, No. 7, pp. 3893-3895.
Prepublished online as a Blood First Edition Paper on January 30, 2008; DOI 10.1182/blood-2007-10-120329.
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Submitted October 25, 2007
Accepted January 28, 2008
The monoclonal anti-VLA4 antibody natalizumab mobilizes CD34+ hematopoietic progenitor cells in humans
Fabian Zohren*, Diamandis Toutzaris, Viola Klarner, Hans-Peter Hartung, Bernd Kieseier, and Rainer Haas
Department of Hematology, Oncology and Clinical Immunology, Heinrich Heine University, Duesseldorf, Germany
Department of Neurology, Heinrich Heine University, Duesseldorf, Germany
* Corresponding author; email: fabian.zohren{at}med.uni-duesseldorf.de.
We investigated the role of adhesion molecule VLA-4 in CD34+ blood stem cell mobilization. Therefore, we examined 20 patients with Multiple Sclerosis (MS) who were treated with the anti-VLA-4 antibody Natalizumab. Treated patients had received a median number of 4 natalizumab infusions (range 2-9). Blood samples were taken four weeks following the last infusion. With a median proportion of 7.6 CD34+ cells/µl (range 2.2-30.4) these patients had a significantly higher (p=0.003) amount of circulating CD34+ cells compared to 5 healthy volunteers (median 1.4, range 0.6-2.4) and 5 untreated MS patients (median 1.0, range 0.5-1.7) (p=0.001). Serial measurements in four patients receiving their first Natalizumab infusion showed a maximal significant increase in circulating CD34+ cells from 3.3/µl (range 1.6-4.8) to 10.4/µl (range 7.5-12.04) 72 hours following Natalizumab infusion (p=0.0005), representing pluripotent progenitors in colony-forming assays. These mobilizing ability of Natalizumab might be useful for patients with poor response to G-CSF based protocols.
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