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Blood, 15 September 2008, Vol. 112, No. 6, pp. 2579-2582. Prepublished online as a Blood First Edition Paper on June 16, 2008June 23, 2008; DOI 10.1182/blood-2007-11-118893. This Article Full Text (PDF) Supplemental Table All Versions of this Article: blood-2007-11-118893v1 blood-2007-11-118893v2 112/6/2579    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Narimatsu, H. Articles by Kato, S. Search for Related Content PubMed PubMed Citation Articles by Narimatsu, H. Articles by Kato, S. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted November 5, 2007 Accepted January 19, 2008 Chronic graft-versus-host disease following umbilical cord blood transplantation: retrospective survey involving 1,072 patients in Japan Hiroto Narimatsu*, Shigesaburo Miyakoshi, Takuhiro Yamaguchi, Masahiro Kami, Tomoko Matsumura, Koichiro Yuji, Naoko Murashige, Eiji Kusumi, Yuko Kodama, Tsunehiko Komatsu, Hisashi Sakamaki, Yasushi Kouzai, Masaya Okada, Yuko Osugi, Ryoji Kobayashi, Masami Inoue, Satoshi Takahashi, Shunro Kai, Koji Kato, Tokiko Inoue-Nagamura, Shuichi Taniguchi, and Shunichi Kato Divison of Exploratory Reaserch, Institute of medical Science, The Uiversity of Tokyo, Tokyo, Japan Japan Cord Blood Bank Network, Tokyo, Japan Department of Clinical Trial Data Management, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan Office for Life-Style Related Diseases Control, Ministry of Health, Labour and Welfare, Tokyo, Japan Department of Hematology, Toranomon Hospital, Tokyo, Japan Third Department of Internal medicine, Teikyo University School of Medicine, Tokyo, Japan Division of Hematology, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan Department of Transfusion, Tokyo Metropolitan Fuchu Hospital, Tokyo, Japan Division of Hematology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan Department of Pediatric Oncology/Hematology, Osaka city general hospital, Osaka, Japan Department of Paediatrics, Hokkaido University Graduate School of Medicine, Sapporo, Japan Department of Hematology/Oncology, Osaka Medical Center and Research Institute for Maternal and Child Health, Osaka, Japan Division of Molecular Therapy, Advanced Clinical Research Ce, Institute of Medical Science, University of Tokyo, Tokyo, Japan * Corresponding author; email: narimt54{at}med.nagoya-u.ac.jp. We have little information on chronic GVHD after cord blood transplantation (CBT). We investigated its clinical features in 1,072 Japanese patients with hematologic malignancies transplanted through the Japan Cord Blood Bank Network. The primary end point was to investigate the incidence of any chronic GVHD. Median age of the patients was 33 years (range, 0-79 years). The cumulative incidence of chronic GVHD 2 year after transplantation was 28%. Chronic GVHD was fatal in 29 patients. Multivariate analysis demonstrated that development of chronic GVHD was favorably associated both with overall survival and event-free survival. Multivariate analysis identified risk factors of chronic GVHD; higher patient's body weight, higher number of mismatched antigens for GVHD direction, myeloablative preparative regimen, use of mycophenolate mofetil in GVHD prophylaxis and development of grade II-IV acute GVHD. Although chronic GVHD is a significant problem after CBT, it is associated with improved survival, perhaps due to graft-versus-malignancy effects. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

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