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Blood, 1 May 2008, Vol. 111, No. 9, pp. 4700-4705. Prepublished online as a Blood First Edition Paper on February 27, 2008; DOI 10.1182/blood-2007-11-122101. This Article Full Text (PDF) All Versions of this Article: blood-2007-11-122101v1 111/9/4700    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Bochtler, T. Articles by Schonland, S. O Search for Related Content PubMed PubMed Citation Articles by Bochtler, T. Articles by Schonland, S. O Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted November 8, 2007 Accepted February 20, 2008 Evaluation of the cytogenetic aberration pattern in amyloid light chain amyloidosis as compared to monoclonal gammopathy of undetermined significance reveals common pathways of karyotypic instability Tilmann Bochtler, Ute Hegenbart, Friedrich W Cremer, Christiane Heiss, Axel Benner, Dirk Hose, Marion Moos, Jelena Bila, Claus R Bartram, Anthony D Ho, Hartmut Goldschmidt, Anna Jauch, and Stefan O Schonland* Department of Internal Medicine, Division of Hematology/Oncology, Amyloidosis Clinic, University of Heidelberg, Heidelberg, Germany Institute of Human Genetics, University Hospital Heidelberg, Heidelberg, Germany Division of Biostatistics, German Cancer Research Center, Heidelberg, Germany National Center for Tumor Diseases Heidelberg, Heidelberg, Germany * Corresponding author; email: stefan.schoenland{at}med.uni-heidelberg.de. Chromosomal aberrations (CA) have emerged as important pathogenetic and prognostic factors in plasma cell disorders. Using interphase FISH analysis, we evaluated CA in a series of 75 amyloid light chain amyloidosis (AL) patients as compared to 127 patients with monoclonal gammopathy of unknown significance (MGUS). We investigated IgH translocations t(11;14), t(4;14), t(14;16) as well as gains of 1q21, 11q23, 19q13 and deletions of 8p21, 13q14 and 17p13 detecting at least one CA in 89% of the patients. Translocation t(11;14) was the most frequent aberration in AL with 47% versus 26% in MGUS (p=0.03) and strongly associated with the lack of an intact immunoglobulin (p<0.001), thus contributing to the frequent light chain subtype in AL. Other frequent aberrations in AL included deletion of 13q14 and gain of 1q21, which were shared by MGUS at comparable frequencies. The progression to MM stage I was paralleled by an increased frequency of gain of 1q21 (p=0.001) in both groups. Similar branching patterns were observed in an oncogenetic tree model indicating a common mechanism of underlying karyotypic instability in these plasma cell disorders. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: R. L. Comenzo How I treat amyloidosis Blood, October 8, 2009; 114(15): 3147 - 3157. [Abstract] [Full Text] [PDF] S. O. Schonland, N. Kroger, C. Wolschke, P. Dreger, A. D. Ho, and U. Hegenbart Donor lymphocyte infusions in amyloid light chain amyloidosis: induction of a "graft-versus-plasma cell-dyscrasia effect" Haematologica, March 1, 2009; 94(3): 439 - 441. [Full Text] [PDF] A. H. Bryce, R. P. Ketterling, M. A. Gertz, M. Lacy, R. A. Knudson, S. Zeldenrust, S. Kumar, S. Hayman, F. Buadi, R. A. Kyle, et al. Translocation t(11;14) and survival of patients with light chain (AL) amyloidosis Haematologica, March 1, 2009; 94(3): 380 - 386. [Abstract] [Full Text] [PDF]

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