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Blood, 15 May 2008, Vol. 111, No. 10, pp. 5008-5016. Prepublished online as a Blood First Edition Paper on March 4, 2008; DOI 10.1182/blood-2007-11-122259. This Article Full Text (PDF) Supplemental Figure All Versions of this Article: blood-2007-11-122259v1 111/10/5008    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Guia, S. Articles by Vivier, E. Search for Related Content PubMed PubMed Citation Articles by Guia, S. Articles by Vivier, E. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted November 14, 2007 Accepted February 20, 2008 A role for interleukin-12/23 in the maturation of human Natural Killer and CD56+ T cells in vivo Sophie Guia, Celine Cognet, Ludovic de Beaucoudrey, Marlowe S Tessmer, Emmanuelle Jouanguy, Claire Berger, Orchidee Filipe-Santos, Jacqueline Feinberg, Yildiz Camcioglu, Jacob Levy, Suliman Al Jumaah, Sami Al-Hajjar, Jean-Louis Stephan, Claire Fieschi, Laurent Abel, Laurent Brossay, Jean-Laurent Casanova, and Eric Vivier* Centre d'Immunologie de Marseille-Luminy, Universite de la Mediterranee, Marseille, France INSERM, U631, and CNRS, UMR6102, Marseille, France Laboratoire de Genetique Humaine des Maladies Infectieuses, Institute National de la Sante et de la Recherche Medicale, U550, Paris, France Department of Molecular Microbiology and Immunology, Brown University, Providence, RI, United States Faculte de Medecine Necker, Universite Paris Rene Descartes, Paris, France Service de Pediatrie, CHU de St Etienne, St Etienne, France Department of Pediatrics, Infectious Diseases, Clinical Immunology and Allergy Division, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey Pediatric Department, Soroka Medical Center, Faculty of Health Science, Ben Gurion University, Beer Sheva, Israel Department of Pediatrics, King Faysal Hospital and Research Center, Riyadh, Saudi Arabia Service d'Immunopathologie, Hopital Saint-Louis, Paris, France Department of Molecular Microbiology and Immunology, Brown University, Providence, RI, France Unite d'Immuno-Hematologie, Hopital Necker, Paris, France Hopital de la Conception, Assistance Publique - Hopitaux de Marseille, Marseille, France * Corresponding author; email: vivier{at}ciml.univ-mrs.fr. Natural Killer (NK) cells have been originally defined by their "naturally-occuring" effector function. However, only a fraction of human NK cells is reactive toward a panel of prototypical tumor cell targets in vitro, both for the production of interferon- (IFN-) and for their cytotoxic response. In patients with IL12RB1 mutations that lead to a complete IL-12R1 deficiency, the size of this "naturally-reactive" NK cell subset is diminished, in particular for the IFN- production. Similar data were obtained from a patient with a complete deficit in IL-12p40. In addition, the size of the subset of effector memory T cells expressing CD56 was severely decreased in IL-12R1- and IL-12p40-deficient patients. Human NK cells thus require in vivo priming with IL-12/23 to acquire their full spectrum of functional reactivity, while T cells are dependent upon IL-12/23 signals for the differentiation and/or the maintenance of CD56+ effector memory T cells. The susceptibility of IL-12/23 axis-deficient patients to Mycobacteria and Salmonella infections in combination with the absence of mycobacteriosis or salmonellosis in the rare cases of human NK cell deficiencies, point to a role for CD56+ T cells in the control of these infections in humans. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: N. Lapaque, T. Walzer, S. Meresse, E. Vivier, and J. Trowsdale Interactions between Human NK Cells and Macrophages in Response to Salmonella Infection J. Immunol., April 1, 2009; 182(7): 4339 - 4348. [Abstract] [Full Text] [PDF] D. van de Wetering, R. A. de Paus, J. T. van Dissel, and E. van de Vosse IL-23 modulates CD56+/CD3- NK Cell and CD56+/CD3+ NK-like T Cell function differentially from IL-12 Int. Immunol., February 1, 2009; 21(2): 145 - 153. [Abstract] [Full Text] [PDF]

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