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Blood, 1 April 2008, Vol. 111, No. 7, pp. 3540-3545. Prepublished online as a Blood First Edition Paper on February 1, 2008; DOI 10.1182/blood-2007-11-122945. This Article Full Text (PDF) All Versions of this Article: blood-2007-11-122945v1 111/7/3540    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Gallinaro, L. Articles by Casonato, A. Search for Related Content PubMed PubMed Citation Articles by Gallinaro, L. Articles by Casonato, A. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted November 9, 2007 Accepted January 26, 2008 A shorter von Willebrand factor survival in O blood group subjects explains how ABO determinants influence plasma von Willebrand factor Lisa Gallinaro, Maria Grazia Cattini, Maryta Sztukowska, Roberto Padrini, Francesca Sartorello, Elena Pontara, Antonella Bertomoro, Viviana Daidone, Antonio Pagnan, and Alessandra Casonato* Department of Medical and Surgical Sciences, Second Chair of Internal Medicine, University of Padua Medical School, Padua, Italy Department of Clinical and Experimental Medicine, University of Padua Medical School, Padua, Italy * Corresponding author; email: sandra.casonato{at}unipd.it. ABO blood groups greatly influence circulating von Willebrand factor (VWF) levels and O group subjects have lower VWF values. In this study, we investigated whether ABO groups affect VWF survival by monitoring the post-DDAVP time courses of VWF antigen (VWF:Ag), VWF collagen binding (VWF:CB) and factor VIII (FVIII) in 47 healthy subjects (28 O and 19 non-O blood groups). The elimination half-life (T1/2el) of VWF was found significantly shorter in O than in non-O subjects (10.0±0.8 hours vs 25.5±5.3 hours, respectively; p<0.01), as was the T1/2el of VWF:CB (7.9±0.5 hours vs 20.9±4.5 hours; p<0.01). A direct linear correlation was found between basal VWF:Ag and T1/2el, subjects with higher VWF levels having longer-surviving VWF. ABO blood groups appeared to strongly influence VWF clearance, but not its synthesis or release from endothelial cells. The VWF propeptide to VWF:Ag ratio, useful for predicting an increased VWF clearance, was found significantly higher in O than in non-O individuals (1.6+/-0.1 vs 1.2+/-0.5, p<0.0005), with values that correlated inversely with T1/2el (p<0.0001). Based on these findings, we conclude that the lower VWF values in O group individuals is attributable to a shorter VWF survival and circulating VWF values are strongly influenced by its half-life. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: B. M. Wolpin and C. S. Fuchs Response: Re: ABO Blood Group and the Risk of Pancreatic Cancer J Natl Cancer Inst, August 19, 2009; 101(16): 1156 - 1157. [Full Text] [PDF] B. Zhang, M. Spreafico, C. Zheng, A. Yang, P. Platzer, M. U. Callaghan, Z. Avci, N. Ozbek, J. Mahlangu, T. Haw, et al. Genotype-phenotype correlation in combined deficiency of factor V and factor VIII Blood, June 15, 2008; 111(12): 5592 - 5600. [Abstract] [Full Text] [PDF]

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