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Blood, 15 August 2008, Vol. 112, No. 4, pp. 1515-1521. Prepublished online as a Blood First Edition Paper on April 14, 2008; DOI 10.1182/blood-2007-11-125542. This Article Full Text (PDF) Supplemental Table and Figure All Versions of this Article: blood-2007-11-125542v1 112/4/1515    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Gatza, E. Articles by Ferrara, J. L. M. Search for Related Content PubMed PubMed Citation Articles by Gatza, E. Articles by Ferrara, J. L. M. Related Collections Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted November 27, 2007 Accepted March 22, 2008 Extracorporeal photopheresis reverses experimental graft-versus-host disease through regulatory T cells Erin Gatza*, Clare E Rogers, Shawn G Clouthier, Kathleen P Lowler, Isao Tawara, Chen Liu, Pavan Reddy, and James L. M. Ferrara Department of Pediatrics, University of Michigan Cancer Center, Ann Arbor, MI, United States Department of Pathology, University of Florida College of Medicine, Gainesville, FL, United States Department of Internal Medicine, University of Michigan Cancer Center, Ann Arbor, MI, United States * Corresponding author; email: egatza{at}umich.edu. Extracorporeal photopheresis (ECP), a technique that exposes isolated white blood cells to photoactivatable 8-methoxypsoralen and ultraviolet A radiation, is used clinically to treat cutaneous T cell lymphoma and immune-mediated diseases such as graft versus host disease (GVHD). ECP is thought to control these diseases in part through direct induction of lymphocyte apoptosis, but its effects on the immune system beyond apoptosis remain poorly characterized. We have developed a novel method for incorporating ECP treatment into well established and clinically relevant murine models of GVHD to examine its effects during an ongoing immune response. We demonstrate that the transfer of cells treated with ECP reverses established GVHD by increasing donor regulatory T cells and indirectly reducing the number of donor effector lymphocytes that themselves had never been exposed to psoralen and ultraviolet A radiation. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: GVHD therapy: let there be light! Krishna V. Komanduri Blood 2008 112: 932-933. [Full Text] [PDF] This article has been cited by other articles: A. Maeda, A. Schwarz, A. Bullinger, A. Morita, D. Peritt, and T. Schwarz Experimental Extracorporeal Photopheresis Inhibits the Sensitization and Effector Phases of Contact Hypersensitivity via Two Mechanisms: Generation of IL-10 and Induction of Regulatory T Cells J. Immunol., November 1, 2008; 181(9): 5956 - 5962. [Abstract] [Full Text] [PDF]

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