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Blood, 7 May 2009, Vol. 113, No. 19, pp. 4790-4798. Prepublished online as a Blood First Edition Paper on December 12, 2008; DOI 10.1182/blood-2007-12-129056. This Article Full Text (PDF) Supplemental Table and Figure All Versions of this Article: blood-2007-12-129056v1 113/19/4790    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Liuba, K. Articles by Jacobsen, S.-E. W. Search for Related Content PubMed PubMed Citation Articles by Liuba, K. Articles by Jacobsen, S.-E. W. Related Collections Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted December 17, 2007 Accepted November 17, 2008 Polyclonal T cell reconstitution of X-SCID recipients following in utero transplantation of lymphoid-primed multipotent progenitors Karina Liuba, Cornelis J.H. Pronk, Simon R.W. Stott, and Sten-Eirik W. Jacobsen* Hematopoietic Stem Cell Laboratory, Lund University, Lund, Sweden Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Lund, Sweden CNS Disease Modelling Unit, Section of Neurobiology, Lund University, Lund, Sweden Haematopoietic Stem Cell Laboratory, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom * Corresponding author; email: sten.jacobsen{at}imm.ox.ac.uk. Although successful in utero hematopoietic cell transplantation (IUHCT) of X-linked severe combined immune deficiency (X-SCID) with enriched stem and progenitor cells was achieved over a decade ago, it remains applied only in rare cases. While this in part reflects that postnatal transplantations have overall given good results, there are no direct comparisons between IUHCT and postnatal transplantations of X-SCID. The proposed tolerance of the fetal immune system to foreign HLA early in gestation, a main rationale behind IUHCT, has recently been challenged by evidence for a considerable immune barrier against in utero transplanted allogeneic bone marrow (BM) cells. Consequently, there is need for further exploring the application of purified stem and progenitor cells to overcome this barrier also in IUHCT. Herein, we demonstrate in a congenic setting, that recently identified lymphoid-primed multipotent progenitors (LMPPs) are superior to hematopoietic stem cells (HSCs) in providing rapid lymphoid reconstitution following IUHCT of X-SCID recipients, and sustain in the long-term B cells, polyclonal T cells, as well as short-lived B cell progenitors and thymic T cell precursors. We further provide evidence for IUHCT of HSCs giving superior B and T cell reconstitution in fetal X-SCID recipients when compared to neonatal and adolescent recipients. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Intrauterine transplantation Magnus Westgren Blood 2009 113: 4484. [Full Text] [PDF] This article has been cited by other articles: M. Westgren Intrauterine transplantation Blood, May 7, 2009; 113(19): 4484 - 4484. [Full Text] [PDF]

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