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Blood, 1 May 2008, Vol. 111, No. 9, pp. 4660-4663. Prepublished online as a Blood First Edition Paper on February 22, 2008; DOI 10.1182/blood-2007-12-130070. This Article Full Text (PDF) All Versions of this Article: blood-2007-12-130070v1 111/9/4660    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Groot, F. Articles by Sattentau, Q. J. Search for Related Content PubMed PubMed Citation Articles by Groot, F. Articles by Sattentau, Q. J. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted December 19, 2007 Accepted February 20, 2008 Efficient HIV-1 transmission from macrophages to T cells across transient virological synapses Fedde Groot*, Sonja Welsch, and Quentin J. Sattentau The Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom * Corresponding author; email: fedde.groot{at}path.ox.ac.uk. Macrophages are reservoirs of HIV-1 infection, proposed to transmit virus to CD4+ T cells, the primary target of the virus. Here we report that human monocyte-derived macrophages (MDM) rapidly spread HIV-1 to autologous CD4+ T cells resulting in productive infection. Transmission takes place across transient adhesive contacts between T cells and MDM, which have the features of a virological synapse including co-polarization of CD4 on the T cell with HIV-1 Gag and Env on the MDM. We propose that an infected MDM can infect at least one T cell every six hours. Since HIV-1-infected macrophages can survive for many weeks, these results highlight the central role played by macrophages in HIV-1 infection and pathogenesis. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: A. Bergamaschi, A. David, E. Le Rouzic, S. Nisole, F. Barre-Sinoussi, and G. Pancino The CDK Inhibitor p21Cip1/WAF1 Is Induced by Fc{gamma}R Activation and Restricts the Replication of Human Immunodeficiency Virus Type 1 and Related Primate Lentiviruses in Human Macrophages J. Virol., December 1, 2009; 83(23): 12253 - 12265. [Abstract] [Full Text] [PDF] C. Muratori, E. Ruggiero, A. Sistigu, R. Bona, and M. Federico Human immunodeficiency virus type 1 (HIV-1) protease inhibitors block cell-to-cell HIV-1 endocytosis in dendritic cells J. Gen. Virol., November 1, 2009; 90(11): 2777 - 2787. [Abstract] [Full Text] [PDF] M. Aubert, M. Yoon, D. D. Sloan, P. G. Spear, and K. R. Jerome The Virological Synapse Facilitates Herpes Simplex Virus Entry into T Cells J. Virol., June 15, 2009; 83(12): 6171 - 6183. [Abstract] [Full Text] [PDF] D. Rudnicka, J. Feldmann, F. Porrot, S. Wietgrefe, S. Guadagnini, M.-C. Prevost, J. Estaquier, A. T. Haase, N. Sol-Foulon, and O. Schwartz Simultaneous Cell-to-Cell Transmission of Human Immunodeficiency Virus to Multiple Targets through Polysynapses J. Virol., June 15, 2009; 83(12): 6234 - 6246. [Abstract] [Full Text] [PDF] M. Noursadeghi, J. Tsang, R. F. Miller, S. Straschewski, P. Kellam, B. M. Chain, and D. R. Katz Genome-Wide Innate Immune Responses in HIV-1-Infected Macrophages Are Preserved Despite Attenuation of the NF-{kappa}B Activation Pathway J. Immunol., January 1, 2009; 182(1): 319 - 328. [Abstract] [Full Text] [PDF] G. Vasiliver-Shamis, M. Tuen, T. W. Wu, T. Starr, T. O. Cameron, R. Thomson, G. Kaur, J. Liu, M. L. Visciano, H. Li, et al. Human Immunodeficiency Virus Type 1 Envelope gp120 Induces a Stop Signal and Virological Synapse Formation in Noninfected CD4+ T Cells J. Virol., October 1, 2008; 82(19): 9445 - 9457. [Abstract] [Full Text] [PDF]

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