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Blood, 15 October 2008, Vol. 112, No. 8, pp. 3355-3361. Prepublished online as a Blood First Edition Paper on August 7, 2008; DOI 10.1182/blood-2008-01-132415. This Article Full Text (PDF) Supplemental Table All Versions of this Article: blood-2008-01-132415v1 112/8/3355    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by van Maldegem, F. Articles by Bende, R. J. Search for Related Content PubMed PubMed Citation Articles by van Maldegem, F. Articles by Bende, R. J. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted January 18, 2008 Accepted July 18, 2008 The majority of cutaneous marginal zone B cell lymphomas express class switched immunoglobulins and develop in a T helper type 2 inflammatory environment Febe van Maldegem, Remco van Dijk, Thera A.M. Wormhoudt, Philip M. Kluin, Rein Willemze, Lorenzo Cerroni, Carel J. M. van Noesel*, and Richard J. Bende Department of Pathology, Academic Medical Center, Amsterdam, Netherlands Department of Pathology and Laboratory Medicine, University Medical Center Groningen, Groningen, Netherlands Department of Dermatology, Leiden University Medical Center, Leiden, Netherlands Department of Dermatology, Medical University of Graz, Graz, Austria * Corresponding author; email: c.j.vannoesel{at}amc.uva.nl. Extranodal marginal zone B cell lymphomas (MZBCLs) arise on a background of chronic inflammation due to organ-specific autoimmunity, infection, or by unknown causes. Well known examples are salivary gland MZBCL in Sjogren's sialadenitis and gastric MZBCL in Helicobacter pylori gastritis. MZBCLs express CXCR3, a receptor for IFN--induced chemokines highly expressed in the chronic inflammatory environment. The immunoglobulin variable heavy/light chain (IgVH/IgVL) gene repertoire of salivary gland- and gastric- MZBCL appears restricted and frequently encodes BCRs with rheumatoid factor (RF) reactivity. Primary cutaneous marginal zone B cell lymphomas (PCMZLs) are regarded as the skin-involving counterpart of extranodal MZBCL. Although PCMZLs have been associated with Borrelia burgdorferi dermatitis, PCMZLs generally arise due to unknown causes. We studied an extensive panel of PCMZLs and show that PCMZLs do not conform to the general profile of extranodal MZBCL. Whereas most non-cutaneous MZBCLs express IgM, PCMZL in majority express IgG, IgA and IgE, and do not show an obvious immunoglobulin repertoire bias. Furthermore, the isotype-switched PCMZLs lack CXCR3 and seem to arise in a different inflammatory environment, as compared to other extranodal MZBCL. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: C. A. Durand, K. Hartvigsen, L. Fogelstrand, S. Kim, S. Iritani, B. Vanhaesebroeck, J. L. Witztum, K. D. Puri, and M. R. Gold Phosphoinositide 3-Kinase p110{delta} Regulates Natural Antibody Production, Marginal Zone and B-1 B Cell Function, and Autoantibody Responses J. Immunol., November 1, 2009; 183(9): 5673 - 5684. [Abstract] [Full Text] [PDF] R. J. Bende, F. van Maldegem, and C. J.M. van Noesel Chronic inflammatory disease, lymphoid tissue neogenesis and extranodal marginal zone B-cell lymphomas Haematologica, August 1, 2009; 94(8): 1109 - 1123. [Abstract] [Full Text] [PDF]

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