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Blood, 15 December 2008, Vol. 112, No. 13, pp. 5150-5160. Prepublished online as a Blood First Edition Paper on September 16, 2008; DOI 10.1182/blood-2008-01-133587. This Article Full Text (PDF) Supplemental Tables All Versions of this Article: blood-2008-01-133587v1 112/13/5150    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Morton, L. M Articles by Hartge, P. Search for Related Content PubMed PubMed Citation Articles by Morton, L. M Articles by Hartge, P. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted January 14, 2008 Accepted July 27, 2008 Etiologic heterogeneity among non-Hodgkin lymphoma subtypes Lindsay M Morton*, Sophia S Wang, Wendy Cozen, Martha S Linet, Nilanjan Chatterjee, Scott Davis, Richard K Severson, Joanne S Colt, Mohammad A Vasef, Nathaniel Rothman, Aaron Blair, Leslie Bernstein, Amanda J Cross, Anneclaire J De Roos, Eric A Engels, David W Hein, Deirdre A Hill, Linda E Kelemen, Unhee Lim, Charles F Lynch, Maryjean Schenk, Sholom Wacholder, Mary H Ward, Shelia Hoar Zahm, Stephen J Chanock, James R Cerhan, and Patricia Hartge Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD, United States Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, United States Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA, United States Department of Family Medicine and Karmanos Cancer Institute, Wayne State University, Detroit, MI, United States Department of Pathology, University of New Mexico, Albuquerque, NM, United States City of Hope Comprehensive Cancer Center, Beckman Research Institute, Duarte, CA, United States Department of Pharmacology and Toxicology and James Graham Brown Cancer Center, University of Louisville, School of Medicine, Louisville, KY, United States Cancer Center and Department of Internal Medicine, University of New Mexico, Albuquerque, NM, United States Mayo Clinic, College of Medicine, Rochester, MN, United States Department of Epidemiology, University of Iowa, Iowa City, IA, United States Core Genotyping Facility, Advanced Technology Center, National Cancer Institute, NIH, DHHS, Gaithersburg, MD, United States * Corresponding author; email: mortonli{at}mail.nih.gov. Understanding patterns of etiologic commonality and heterogeneity for non-Hodgkin lymphomas may illuminate lymphomagenesis. We present the first systematic comparison of risks by lymphoma subtype for a broad range of putative risk factors in a population-based case-control study, including diffuse large B-cell (DLBCL; N=416), follicular (N=318), and marginal zone lymphomas (N=106), and chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL; N=133). We required at least two of three analyses to support differences in risk: 1) polytomous logistic regression, 2) homogeneity tests, or 3) dichotomous logistic regression, analyzing all seven possible pairwise comparisons among the subtypes, corresponding to various groupings by clinical behavior, genetic features, and differentiation. Late birth order and high body mass index (35kg/m2) increased risk for DLBCL alone. Autoimmune conditions increased risk for marginal zone lymphoma alone. The tumor necrosis factor G-308A polymorphism (rs1800629) increased risks for both DLBCL and marginal zone lymphoma. Exposure to certain dietary heterocyclic amines from meat consumption increased risk for CLL/SLL alone. We observed no significant risk factors for follicular lymphoma alone. These data clearly support both etiologic commonality and heterogeneity for lymphoma subtypes, suggesting that immune dysfunction is of greater etiologic importance for DLBCL and marginal zone lymphoma than for CLL/SLL and follicular lymphoma. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: A. M. Evens and B. C.-H. Chiu The Challenges of Epidemiologic Research in Non-Hodgkin Lymphoma JAMA, November 5, 2008; 300(17): 2059 - 2061. [Full Text] [PDF]

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