SEARCH:   Advanced

Blood, 1 October 2008, Vol. 112, No. 7, pp. 2990-2995. Prepublished online as a Blood First Edition Paper on May 20, 2008; DOI 10.1182/blood-2008-01-135285. This Article Full Text (PDF) All Versions of this Article: blood-2008-01-135285v1 112/7/2990    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Stern, M. Articles by Velardi, A. Search for Related Content PubMed PubMed Citation Articles by Stern, M. Articles by Velardi, A. Related Collections Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted January 23, 2008 Accepted April 13, 2008 Survival after T-cell depleted haploidentical stem cell transplantation is improved using the mother as donor Martin Stern*, Loredana Ruggeri, Antonella Mancusi, Maria Ester Bernardo, Claudia de Angelis, Christoph Bucher, Franco Locatelli, Franco Aversa, and Andrea Velardi Department of Hematology, University Hospital Basel, Basel, Switzerland Division of Hematology & Clinical Immunology, University of Perugia, Perugia, Italy Oncoematologia Pediatrica, Fondazione IRCCS Policlinico San Matteo, Universita di Pavia, Pavia, Italy Department of Pediatrics, Division of Hematology-Oncology, Blood and Marrow Transplantation, University of Minnesota, Minneapolis, MN, United States * Corresponding author; email: sternm{at}uhbs.ch. We hypothesized that transplacental leukocyte trafficking during pregnancy, which induces long-term, stable, reciprocal microchimerism in mother and child, might influence outcome of patients with acute leukemia given parental donor haploidentical hematopoietic stem cell transplantation (HSCT). We analyzed the outcome of 118 patients transplanted for acute leukemia in two centers. Patients received highly T-cell depleted haploidentical grafts after myeloablative conditioning. Five-year event-free survival was better in patients transplanted from the mother than from the father (50.6 ± 7.6% versus 11.1 ± 4.2%, p<0.0001). Better survival was the result of both reduced incidence of relapse and transplantation-related mortality. The protective effect was seen in both female and male recipients, in both lymphoid and myeloid diseases; it was more evident in patients transplanted in remission than in chemo-resistant relapse. Incidences of rejection and acute graft-versus-host disease were not significantly influenced. Multivariate analysis confirmed donor gender in parental donor transplants as an independent prognostic factor for survival (hazard ratio father vs mother 2.36, p=0.003). In contrast, in a control cohort of patients transplanted from haploidentical siblings, donor gender had no influence on outcome. Although obtained in a retrospective analysis, these data suggest that the mother of the patient should be preferred as donor for haploidentical HSCT. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Mother and child reunion Jan J. Cornelissen Blood 2008 112: 2604-2605. [Full Text] [PDF] This article has been cited by other articles: F. Locatelli Tolerance: pregnancy matters Blood, September 10, 2009; 114(11): 2208 - 2209. [Full Text] [PDF] A. G. S. van Halteren, E. Jankowska-Gan, A. Joosten, E. Blokland, J. Pool, A. Brand, W. J. Burlingham, and E. Goulmy Naturally acquired tolerance and sensitization to minor histocompatibility antigens in healthy family members Blood, September 10, 2009; 114(11): 2263 - 2272. [Abstract] [Full Text] [PDF]

	Copyright © 2008 by American Society of Hematology         Online ISSN: 1528-0020