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Blood, 15 August 2008, Vol. 112, No. 4, pp. 1325-1328. Prepublished online as a Blood First Edition Paper on April 17, 2008; DOI 10.1182/blood-2008-01-135335. This Article Full Text (PDF) All Versions of this Article: blood-2008-01-135335v1 112/4/1325    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Yu, J. Articles by Yazdanbakhsh, K. Search for Related Content PubMed PubMed Citation Articles by Yu, J. Articles by Yazdanbakhsh, K. Related Collections Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted January 28, 2008 Accepted April 5, 2008 Defective circulating CD25 regulatory T cells in patients with chronic immune thrombocytopenic purpura Jin Yu, Susanne Heck, Vivek Patel, Jared Levan, Yu Yu, James B. Bussel, and Karina Yazdanbakhsh* Laboratory of Complement Biology, New York Blood Center, New York, NY, United States Flow Cytometry Laboratory, New York Blood Center, New York, NY, United States Department of Pediatrics, Weill Medical College of Cornell University, New York, NY, United States * Corresponding author; email: kyazdanbakhsh{at}nybloodcenter.org. Immune thrombocytopenic purpura (ITP) is characterized by the presence of anti-platelet autoantibodies as a result of loss of tolerance. CD4+CD25+ regulatory T cells (Tregs) are important for maintenance of peripheral tolerance. Decreased levels of peripheral Tregs in patients with ITP have been reported. To test whether inefficient production or reduced immunosuppressive activity of Tregs contributes to loss of tolerance in patients with chronic ITP, we investigated the frequency and function of their circulating CD4+CD25hi Tregs. We found a comparable frequency of circulating CD4+CD25hiFoxp3+ Tregs in patients and controls (n=16, p>0.05). However, sorted CD4+CD25hi cells from patients with chronic ITP (n=13) had a two fold reduction of in vitro immunosuppressive activity compared to controls (n=10, p<0.05). The impaired suppression was specific to Tregs as shown by cross-mixing experiments with T cells from controls. These data suggest that functional defects in Tregs contribute to breakdown of self-tolerance in patients with chronic ITP. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: ITP three R's: regulation, routing, rituximab John W. Semple Blood 2008 112: 927-928. [Full Text] [PDF] This article has been cited by other articles: J. Zhang, D. Ma, X. Zhu, X. Qu, C. Ji, and M. Hou Elevated profile of Th17, Th1 and Tc1 cells in patients with immune thrombocytopenic purpura Haematologica, September 1, 2009; 94(9): 1326 - 1329. [Full Text] [PDF] S. Andre, D. F. Tough, S. Lacroix-Desmazes, S. V. Kaveri, and J. Bayry Surveillance of Antigen-Presenting Cells by CD4+CD25+ Regulatory T Cells in Autoimmunity: Immunopathogenesis and Therapeutic Implications Am. J. Pathol., May 1, 2009; 174(5): 1575 - 1587. [Abstract] [Full Text] [PDF] J. W. Semple Platelet antigen-induced regulation in ITP Blood, March 12, 2009; 113(11): 2373 - 2373. [Full Text] [PDF] X.-L. Zhang, J. Peng, J.-Z. Sun, J.-J. Liu, C.-S. Guo, Z.-G. Wang, Y. Yu, Y. Shi, P. Qin, S.-G. Li, et al. De novo induction of platelet-specific CD4+CD25+ regulatory T cells from CD4+CD25- cells in patients with idiopathic thrombocytopenic purpura Blood, March 12, 2009; 113(11): 2568 - 2577. [Abstract] [Full Text] [PDF] Fresh Insights into Chronic Immune Thrombocytopenic Purpura Journal Watch Oncology and Hematology, September 23, 2008; 2008(923): 2 - 2. [Full Text]

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