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Blood, 15 August 2008, Vol. 112, No. 4, pp. 1374-1381. Prepublished online as a Blood First Edition Paper on May 28, 2008; DOI 10.1182/blood-2008-01-136465. This Article Full Text (PDF) Supplemental Tables and Figures All Versions of this Article: blood-2008-01-136465v1 112/4/1374    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Klapper, W. Articles by Siebert, R. Search for Related Content PubMed PubMed Citation Articles by Klapper, W. Articles by Siebert, R. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted January 28, 2008 Accepted May 3, 2008 Molecular profiling of pediatric mature B-cell lymphoma treated in population-based prospective clinical trials Wolfram Klapper*, Monika Szczepanowski, Birgit Burkhardt, Hilmar Berger, Maciej Rosolowski, Stefan Bentink, Carsten Schwaenen, Swen Wessendorf, Rainer Spang, Peter Moller, Martin Leo Hansmann, Heinz-Wolfram Bernd, German Ott, Michael Hummel, Harald Stein, Markus Loeffler, Lorenz Trumper, Martin Zimmermann, Alfred Reiter, and Reiner Siebert Department of Pathology, Hematopathology Section and Lymph Node Registry, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany Children’s University Hospital, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany Institute of Functional Genomics, University of Regensburg, Regensburg, Germany Cytogenetic and Molecular Diagnostics, Internal Medicine III, University Hospital of Ulm, Ulm, Germany Institute of Pathology, University Hospital of Ulm, Ulm, Germany Institute of Pathology, University of Frankfurt, Frankfurt, Germany Institute of Pathology, University Hospital Schleswig-Holstein, Campus Lubeck, Lubeck, Germany Institute of Clinical Pathology, Robert-Bosch-Krankenhaus, Stuttgart, Germany Institute of Pathology, Campus Benjamin Franklin, Charite Universitatsmedizin, Berlin, Germany Department of Hematology and Oncology, Georg-August University of Gottingen, Gottingen, Germany Department of Pediatric Hematology and Oncology, University of Hannover, Germany NHL-BFM Study Center, Department of Pediatric Hematology and Oncology, Justus-Liebig-University, Giessen, Germany Institute of Human Genetics, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany * Corresponding author; email: wklapper{at}path.uni-kiel.de. The spectrum of entities, the therapeutic strategy and the outcome of mature aggressive B-cell Non-Hodgkin lymphomas (maB-NHL) differs between children and adolescents on the one hand and adult patients on the other. Whereas adult maB-NHL have been studied in detail, data on molecular profiling of pediatric maB-NHL are hitherto lacking. We analyzed 65 cases of maB-NHL from patients up to 18 years of age by gene expression profiling, matrix CGH, FISH and immunohistochemistry. The majority of the analyzed pediatric patients were treated within prospective trials (n=49). We compared this group to a series of 182 previously published cases of adult maB-NHL. Gene expression profiling reclassified 31% of morphologically defined diffuse large B-cell lymphomas as molecular Burkitt lymphoma (mBL). The subgroups obtained by molecular reclassification did not show any difference in outcome in children treated with the NHL-BFM protocols. No differences were detectable between pediatric and adult mBL with regard to gene expression or chromosomal imbalances. This is the first report on molecular profiling of pediatric B-NHL showing mBL to be much more prominent in children than suggested by morphological assessment. Based on molecular profiling mBL is a molecularly homogeneous disease across children and adults. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: U. Bacher, A. Kohlmann, and T. Haferlach Perspectives of gene expression profiling for diagnosis and therapy in haematological malignancies Brief Funct Genomic Proteomic, May 27, 2009; (2009) elp011v1. [Abstract] [Full Text] [PDF]

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