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Blood, 15 August 2008, Vol. 112, No. 4, pp. 1317-1324. Prepublished online as a Blood First Edition Paper on June 6, 2008; DOI 10.1182/blood-2008-01-136713. This Article Full Text (PDF) Supplemental Figures All Versions of this Article: blood-2008-01-136713v1 112/4/1317    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Pitard, V. Articles by Dechanet-Merville, J. Search for Related Content PubMed PubMed Citation Articles by Pitard, V. Articles by Dechanet-Merville, J. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted January 29, 2008 Accepted May 27, 2008 Long term expansion of effector/memory V2neg T cells is a specific blood signature of CMV infection Vincent Pitard, David Roumanes, Xavier Lafarge, Lionel Couzi, Isabelle Garrigue, Marie-Edith Lafon, Pierre Merville, Jean-Francois Moreau, and Julie Dechanet-Merville* Universite Bordeaux 2, Bordeaux, France CNRS UMR 5164, Universite Bordeaux 2, Bordeaux, France Departement de Nephrologie et Transplantation Renale, CHU Bordeaux, Bordeaux, France Laboratoire de Virologie, CHU Bordeaux, Bordeaux, France Laboratoire d'Immunologie, CHU Bordeaux, France, France * Corresponding author; email: julie.dechanet{at}u-bordeaux2.fr. The ability of human T cells to develop immunological memory is still a matter of debate. We have previously demonstrated the involvement of V2neg T lymphocytes in the response of immunosuppressed organ recipients to CMV. Herein, we demonstrate their ability to mount an adaptive immune response to CMV in immunocompetent subjects. V2neg T cell peripheral blood numbers, repertoire restriction and cytotoxicity against CMV-infected fibroblasts were markedly increased in CMV-seropositive, in comparison to CMV-seronegative, healthy individuals. While V2neg T cells were found as naive cells in CMV- individuals, they virtually all exhibited the cytotoxic effector/memory phenotype in CMV+ individuals which is also observed in transplant patients challenged with CMV. This long-term complete remodeling of the V2neg T cell population by CMV predicts their ability to exhibit an adaptive anti-CMV response. Consistent with this, we observed that the secondary response to CMV was associated with a faster T cell expansion and a better resolution of infection than the primary response. In conclusion, the increased level of effector-memory V2neg T cells in the peripheral blood is a specific signature of an adaptive immune response to CMV infection of both immunocompetent and immunosuppressed individuals. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: L. Shao, D. Huang, H. Wei, R. C. Wang, C. Y. Chen, L. Shen, W. Zhang, J. Jin, and Z. W. Chen Expansion, Reexpansion, and Recall-Like Expansion of V{gamma}2V{delta}2 T Cells in Smallpox Vaccination and Monkeypox Virus Infection J. Virol., November 15, 2009; 83(22): 11959 - 11965. [Abstract] [Full Text] [PDF] L. T. van der Veken, M. Coccoris, E. Swart, J. H. F. Falkenburg, T. N. Schumacher, and M. H. M. Heemskerk {alpha}{beta} T Cell Receptor Transfer to {gamma}{delta} T Cells Generates Functional Effector Cells without Mixed TCR Dimers In Vivo J. Immunol., January 1, 2009; 182(1): 164 - 170. [Abstract] [Full Text] [PDF]

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