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Blood, 1 January 2009, Vol. 113, No. 1, pp. 137-148. Prepublished online as a Blood First Edition Paper on August 14, 2008; DOI 10.1182/blood-2008-02-140616. This Article Full Text (PDF) Supplemental Figures All Versions of this Article: blood-2008-02-140616v1 113/1/137    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Cheung, K-J. J Articles by Horsman, D. E Search for Related Content PubMed PubMed Citation Articles by Cheung, K-J. J Articles by Horsman, D. E Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted February 22, 2008 Accepted June 22, 2008 Genome-wide profiling of follicular lymphoma by array comparative genomic hybridization reveals prognostically significant DNA copy number imbalances K-John J Cheung, Sohrab P Shah, Christian Steidl, Nathalie Johnson, Thomas Relander, Adele Telenius, Betty Lai, Kevin P Murphy, Wan Lam, Abdulwahab J Al-Tourah, Joseph M Connors, Raymond T Ng, Randy D Gascoyne, and Douglas E Horsman* Center for Lymphoid Cancer, British Columbia Cancer Agency, Vancouver, BC, Canada Department of Computer Science, University of British Columbia, Vancouver, BC, Canada Cancer Genetics and Developmental Biology, British Columbia Cancer Research Center, Vancouver, BC, Canada * Corresponding author; email: dhorsman{at}bccancer.bc.ca. The secondary genetic events associated with follicular lymphoma (FL) progression are not well defined. We applied genome-wide BAC array comparative genomic hybridization to 106 diagnostic biopsies of FL to characterize regional genomic imbalances. Using an analytical approach that defined regions of copy number change as intersections between visual annotations and a Hidden Markov model-based algorithm, we identified 71 regional alterations that were recurrent in 10% of cases. These ranged in size from ~200 kb to 44 Mb, affecting chromosomes 1, 5, 6, 7, 8, 10, 12, 17, 18, 19, and 22. We also demonstrated by cluster analysis that 46.2% of the 106 cases could be sub-grouped based on the presence of +1q, +6p/6q-, +7 or +18. Survival analysis showed that 21 of the 71 regions correlated significantly with inferior overall survival (OS). Of these 21 regions, 16 were independent predictors of OS using a multivariate Cox model that included the International Prognostic Index (IPI) Score. Two of these 16 regions (1p36.22-p36.33 and 6q21-q24.3) were also predictors of transformation risk and independent of IPI. These prognostic features may be useful to identify high-risk patients as candidates for risk-adapted therapies. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: D. O'Shea, C. O'Riain, M. Gupta, R. Waters, Y. Yang, D. Wrench, J. Gribben, A. Rosenwald, G. Ott, L. M. Rimsza, et al. Regions of acquired uniparental disomy at diagnosis of follicular lymphoma are associated with both overall survival and risk of transformation Blood, March 5, 2009; 113(10): 2298 - 2301. [Abstract] [Full Text] [PDF]

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