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Blood, 12 March 2009, Vol. 113, No. 11, pp. 2416-2425. Prepublished online as a Blood First Edition Paper on January 15, 2009; DOI 10.1182/blood-2008-03-144121. This Article Full Text (PDF) Supplemental Tables and Figures All Versions of this Article: blood-2008-03-144121v1 113/11/2416    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Cho, S. H. Articles by Boothby, M. Search for Related Content PubMed PubMed Citation Articles by Cho, S. H. Articles by Boothby, M. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted March 7, 2008 Accepted January 1, 2009 PARP-14, a member of the B aggressive lymphoma (BAL) family, transduces survival signals in primary B cells Sung Hoon Cho, Shreevrat Goenka, Tiina Henttinen, Prathyusha Gudapati, Arja Reinikainen, Christine M. Eischen, Riitta Lahesmaa, and Mark Boothby* Department of Microbiology & Immunology, Vanderbilt University, Nashville, TN, United States Centre for Biotechnology, University of Turku, Turku, Finland Department of Pathology, Vanderbilt Univeristy, Nashville, TN, United States Department of Medicine, Vanderbilt University, Nashville, TN, United States * Corresponding author; email: mark.boothby{at}vanderbilt.edu. Poly(ADP-ribos)ylation is one of the longest-known but most enigmatic post-translational modifications transducing specific signals. The enzyme responsible for the majority of poly(ADP-ribose) polymerization in cells, PARP-1, promotes DNA repair but also mediates a caspase-independent form of apoptosis in response to stressors such as irradiation. However, the biological function of most other PARPs is not known. Macro-PARPs constitute one branch of the large family of PARP-like proteins also designated as B Aggressive Lymphoma proteins (BAL1, 2a/2b, 3, or PARP-9, -14, and -15). To elucidate biological role(s) of a BAL-family macro-PARP, we analyzed mice deficient in PARP-14, a binding partner of the IL-4-induced transcription factor Stat6. We show here that PARP-14 plays a fundamental role mediating protection against apoptosis in IL-4-treated B cells, including that following DNA damage, and mediates IL-4 effects on the levels of gene products that regulate cell survival, proliferation, and lymphomagenesis. Collectively, the results establish that PARP-14 mediates regulation of gene expression and lymphocyte physiology by IL-4 and has a function distinct from PARP-1. Furthermore, the findings suggest mechanisms by which BAL-family proteins might influence pathological processes involving B lymphocytes. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: S. Teotia and R. S. Lamb The Paralogous Genes RADICAL-INDUCED CELL DEATH1 and SIMILAR TO RCD ONE1 Have Partially Redundant Functions during Arabidopsis Development Plant Physiology, September 1, 2009; 151(1): 180 - 198. [Abstract] [Full Text] [PDF]

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