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 Blood, 1 August 2008, Vol. 112, No. 3, pp. 840-843.
Prepublished online as a Blood First Edition Paper on June 2, 2008; DOI 10.1182/blood-2008-03-144576.

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Submitted March 10, 2008
Accepted May 6, 2008

No convincing evidence for a role of CD31-CD38 interactions in the pathogenesis of chronic lymphocytic leukemia

Sanne H Tonino*, Rene Spijker, Dieuwertje M.P. Luijks, Marinus H J van Oers, and Arnon P Kater

department of Hematology, Academic Medical Center, Amsterdam, Netherlands
department of Experimental Immunology, Academic Medical Center, Amsterdam, Netherlands

* Corresponding author; email: s.h.tonino{at}amc.uva.nl.

Although CD38, a marker of poor prognosis in chronic lymphocytic leukemia (CLL), is primarily known as an ecto-enzyme, it has also been ascribed a receptor function. Interaction with its proposed ligand CD31 expressed on nurse-like cells would result in proliferative and survival-signals. Yet, in CLL, both homotypic and heterotypic CD31-CD38 interactions are expected to be rather ubiquitous. We analyzed whether CD38-CD31 interactions result in proliferative and anti-apoptotic signals. We found a high expression of CD31 on CLL, irrespective of CD38 expression. Co-culture of CD38high CLL with endothelial cells or CD31 transfected fibroblasts, with or without blocking CD31- or CD38-antibodies, did not result in increased survival or proliferation. Analysis of gene-expression of most known regulators of apoptosis revealed no influence of co-culture with CD31-expressing feeder cells. In conclusion, our data do not support an important contribution of CD38 triggering by CD31 to the proliferative, and anti-apoptotic, state of the leukemic clone.


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