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Blood, 8 January 2009, Vol. 113, No. 2, pp. 358-369. Prepublished online as a Blood First Edition Paper on October 15, 2008; DOI 10.1182/blood-2008-03-145615. This Article Full Text (PDF) All Versions of this Article: blood-2008-03-145615v1 113/2/358    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Kuttruff, S. Articles by Steinle, A. Search for Related Content PubMed PubMed Citation Articles by Kuttruff, S. Articles by Steinle, A. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted March 24, 2008 Accepted September 15, 2008 NKp80 defines and stimulates a reactive subset of CD8 T cells Sabrina Kuttruff, Sven Koch, Alexandra Kelp, Graham Pawelec, Hans-Georg Rammensee, and Alexander Steinle* Department of Immunology, Institute for Cell Biology, University of Tuebingen, Tuebingen, Germany Center for Medical Research (ZMF), University of Tuebingen, Tuebingen, Germany * Corresponding author; email: alexander.steinle{at}uni-tuebingen.de. NKp80, an activating homodimeric C-type lectin-like receptor (CTLR), is expressed on essentially all human NK cells and stimulates their cytotoxicity and cytokine release. Recently, we demonstrated that the ligand for NKp80 is the myeloid-specific CTLR AICL which is encoded in the Natural Killer Gene complex (NKC) adjacent to NKp80. Here we show that NKp80 is also expressed on a minor fraction of human CD8 T cells which exhibit a high responsiveness and an effector memory phenotype. Gene expression profiling and flow cytometric analyses revealed that this NKp80+ T cells subset is characterized by the co-expression of other NK receptors and increased levels of cytotoxic effector molecules and adhesion molecules mediating access to sites of inflammation. NKp80 ligation augmented CD3-stimulated degranulation and IFN secretion by effector memory T cells. Further, engagement of NKp80 by AICL-expressing transfectants or macrophages markedly enhanced CD8 T cell responses in alloreactive settings. Collectively, our data demonstrate that NKp80 is expressed on a highly responsive subset of effector memory CD8 T cells with an inflammatory NK-like phenotype and promotes T cell responses towards AICL-expressing cells. Hence, NKp80 may enable effector memory CD8 T cells to functionally interact with cells of myeloid origin at sites of inflammation. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: P. Thebault, N. Lhermite, G. Tilly, L. Le Texier, T. Quillard, M. Heslan, I. Anegon, J.-P. Soulillou, S. Brouard, B. Charreau, et al. The C-Type Lectin-Like Receptor CLEC-1, Expressed by Myeloid Cells and Endothelial Cells, Is Up-Regulated by Immunoregulatory Mediators and Moderates T Cell Activation J. Immunol., September 1, 2009; 183(5): 3099 - 3108. [Abstract] [Full Text] [PDF]

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