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Blood, 22 January 2009, Vol. 113, No. 4, pp. 911-918. Prepublished online as a Blood First Edition Paper on October 16, 2008; DOI 10.1182/blood-2008-03-147892. This Article Full Text (PDF) Supplemental Figure All Versions of this Article: blood-2008-03-147892v1 113/4/911    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Perry, J. M Articles by Paulson, R. F. Search for Related Content PubMed PubMed Citation Articles by Perry, J. M Articles by Paulson, R. F. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted March 28, 2008 Accepted September 24, 2008 Maintenance of the BMP4 dependent stress erythropoiesis pathway in the murine spleen requires hedgehog signaling John M Perry, Omid F Harandi, Prashanth Porayette, Shailaja Hegde, Arun K Kannan, and Robert F. Paulson* Cell and Developmental Biology Option, The Pennsylvania State University, University Park, PA, United States Graduate Program in Genetics, The Pennsylvania State University, University Park, PA, United States Molecular Medicine Option, The Pennsylvania State University, University Park, PA, United States Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA, United States Center for Molecular Immunology and Infectious Disease, The Pennsylvania State University, University Park, PA, United States * Corresponding author; email: rfp5{at}psu.edu. The production of mature cells necessitates that lineage committed progenitor cells be constantly generated from multipotential progenitors. In addition, the ability to rapidly respond to physiological stresses requires that the signals that regulate the maintenance of progenitor populations be coordinated with the signals that promote differentiation of progenitors. Here we examine the signals that are necessary for the maintenance of the BMP4 dependent stress erythropoiesis pathway. Our previous work demonstrated that BMP4, SCF and hypoxia act in concert to promote the expansion of a specialized population of stress erythroid progenitors in the spleen during the recovery from acute anemia. Our analysis shows that acute anemia leads to an almost complete mobilization of BMP4 responsive stress BFU-E; therefore, new stress progenitors must be recruited to the spleen to replenish this system. We show that bone marrow cells can home to the spleen and in response to a signal in the spleen microenvironment, Hedgehog, they develop into BMP4 responsive stress progenitors. Hedgehog induces the expression of BMP4 and together these two signals are required for the development of BMP4 responsive stress progenitors. These data demonstrate that the interplay between these two signals is crucial for maintenance of this stress response pathway. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: W.-K. Kim, V. Meliton, K. W. Park, C. Hong, P. Tontonoz, P. Niewiadomski, J. A. Waschek, S. Tetradis, and F. Parhami Negative Regulation of Hedgehog Signaling by Liver X Receptors Mol. Endocrinol., October 1, 2009; 23(10): 1532 - 1543. [Abstract] [Full Text] [PDF] A. R. Migliaccio, F. Martelli, M. Verrucci, M. Sanchez, M. Valeri, G. Migliaccio, A. M. Vannucchi, M. Zingariello, A. Di Baldassarre, B. Ghinassi, et al. Gata1 expression driven by the alternative HS2 enhancer in the spleen rescues the hematopoietic failure induced by the hypomorphic Gata1low mutation Blood, September 3, 2009; 114(10): 2107 - 2120. [Abstract] [Full Text] [PDF]

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