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 Blood, 1 September 2008, Vol. 112, No. 5, pp. 2163-2166.
Prepublished online as a Blood First Edition Paper on June 18, 2008; DOI 10.1182/blood-2008-04-148130.

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Submitted April 14, 2008
Accepted May 27, 2008

Association between BMI-1 expression, acute graft-versus-host disease and outcome following allogeneic stem cell transplantation from HLA-identical siblings in chronic myeloid leukemia

Mohamad Mohty, Richard M Szydlo, Agnes SM Yong, Jane F Apperley, John M Goldman, and Junia V Melo*

Department of Haematology, Imperial College & Hammersmith Hospital, London, United Kingdom

* Corresponding author; email: junia.melo{at}imvs.sa.gov.au.

Expression of CD7, ELA-2, PR-3 and the polycomb group gene BMI-1 reflects the intrinsic heterogeneity and predicts prognosis of chronic myeloid leukemia (CML) patients who were not treated with allogeneic stem cell transplantation (allo-SCT). This study investigated whether expression of these genes determined outcome following allo-SCT in a cohort of 84 chronic phase (CP) CML patients. We found that patients expressing BMI-1 at 'high' level before allo-SCT had an improved overall survival (P=0.005) related to a reduced transplant-related mortality. In multivariate analysis, when adjusted for the EBMT-Gratwohl score and other prognostic factors, there was an independent association between BMI-1 expression and grade 2-4 acute graft-versus-host disease (RR=2.85, 95%CI; 1.3-6.4; P=0.011) suggesting that BMI-1 measured prior to allo-SCT can serve as a biomarker for predicting outcome in CP-CML patients receiving allo-SCT, and may thus contribute to better therapeutic decisions.


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C. H. Jamieson
Chronic Myeloid Leukemia Stem Cells
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